Intrinsically disordered regions and proteins are common. The protein has not traditionally defined structure in these regions, instead can adopt different conformations and often interact with many partners. PON-IDR is the first dedicated predictor for amino acid tolerance/pathogenicity due to substitutions. The method is based on gradient boost decision tree (GBDT) and has a good performance in blind test analysis. The method was developed in collaboration between the groups of Prof. Mauno Vihinen in Lund University and Assoc. Prof. Yang Yang in Soochow University.
You can input UIDs, sequences and variations of proteins. And you can also upload relevant files.
Result are displayed on the Results page. You can also provide your email, then the results are by email.