Gene	Uniprot_Accession	Variation	Clinical_significance	Review_status	Chromosome	Location	PON-P2_predicted_probability_of_harmfulness
DSC2	Q02487	R203C	Likely pathogenic(Last reviewed: Nov 12, 2014)	classified by single submitter	18	31089462	0.643
ACTG2	P63267	G269E	Pathogenic	classified by single submitter	2	73916584 - 73916585	0.661
TSC2	P49815	R611Q	Pathogenic, not provided, other(Last reviewed: Aug 16, 2013)	classified by single submitter	16	2070571	0.853
RYR1	P21817	R163C	Pathogenic, not provided, risk factor(Last reviewed: Sep 17, 2013)	classified by single submitter	19	38444211	0.703
ATM	Q13315	V2424G	Pathogenic, risk factor(Last reviewed: Nov 22, 2014)	classified by multiple submitters	11	108329202	0.86
CYP17A1	P05093	R125Q	Pathogenic(Last reviewed: Apr 30, 2015)	classified by single submitter	10	102835316	0.907
TP53	P04637	P151S	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	17	7675161	0.858
TSHR	P16473	L629F	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	14	81143945	0.256
TSHR	P16473	F631L	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	14	81143949	0.339
KCNJ5	P48544	T158A	Pathogenic(Last reviewed: Aug 26, 2014)	classified by single submitter	11	128911745	0.737
PIK3CA	P42336	H1047L	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	3	179234297	0.695
AKT1	P31749	E17K	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	14	104780214	0.794
HRAS|LRRC56	P01112	G12C	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	11	534289	0.789
HRAS|LRRC56	P01112	G12D	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	11	534288	0.976
KRAS	P01116	G12V	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	12	25245350	0.719
PTPN11	Q06124	E76A	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	12	112450407	0.974
FGFR3	P22607	K650E	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	4	1806162	0.931
PTPN11	Q06124	E76K	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	12	112450406	0.98
PIK3CA	P42336	C420R	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	3	179210192	0.884
FGFR2	P21802	S267P	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	10	121520119	0.868
PDGFRA	P16234	V561D	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	4	54274869	0.92
PIK3CA	P42336	E542K	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	3	179218294	0.739
FGFR3	P22607	G370C	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	4	1804362	0.942
FGFR2	P21802	Y375C	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	10	121515280	0.954
FGFR2	P21802	S252W	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	10	121520163	0.827
FGFR3	P22607	S249C	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	4	1801841	0.849
PIK3CA	P42336	E545K	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	3	179218303	0.922
HRAS|LRRC56	P01112	G12S	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	11	534289	0.937
PIK3CA	P42336	H1047R	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	3	179234297	0.802
SDHD	O14521	P81L	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	11	112088939	0.479
FGFR3	P22607	G380R	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	4	1804392	0.913
HRAS|LRRC56	P01112	G12V	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	11	534288	0.973
FGFR3	P22607	R248C	Pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	4	1801837	0.951
TGFBR2	P37173	R528H	Pathogenic(Last reviewed: Aug 29, 2014)	classified by multiple submitters	3	30691478	0.951
TNNI2	P48788	R174Q	Pathogenic(Last reviewed: Dec 1, 2008)	classified by single submitter	11	1841523	0.748
NRAS	P01111	G12S	Pathogenic(Last reviewed: Dec 2, 2013)	classified by multiple submitters	1	114716127	0.878
SCN11A	Q9UI33	R225C	Pathogenic(Last reviewed: Dec 4, 2013)	classified by single submitter	3	38925454	0.423
GLB1	P16278	R59H	Pathogenic(Last reviewed: Feb 18, 2013)	classified by multiple submitters	3	33072613	0.978
RET	P07949	M918T	Pathogenic(Last reviewed: Feb 18, 2015)	classified by multiple submitters	10	43121968	0.964
BRCA2	P51587	R2336L	Pathogenic(Last reviewed: Feb 20, 2013)	classified by single submitter	13	32346896	0.283
NRAS	P01111	G13D	Pathogenic(Last reviewed: Jan 15, 2015)	classified by multiple submitters	1	114716123	0.966
PTPN11	Q06124	D61G	Pathogenic(Last reviewed: Jan 15, 2015)	classified by multiple submitters	12	112450362	0.946
PTPN11	Q06124	E139D	Pathogenic(Last reviewed: Jan 15, 2015)	classified by multiple submitters	12	112453279	0.91
BRCA1	P38398	C61G	Pathogenic(Last reviewed: Jan 28, 2015)	classified by multiple submitters	17	43106487	0.784
ALB	P02768	E594K	Pathogenic(Last reviewed: Jun 6, 2012)	classified by single submitter	4	73419634	0.331
BRAF	P15056	G469R	Pathogenic(Last reviewed: Mar 11, 2015)	classified by multiple submitters	7	140781603	0.856
TERT	O14746	R979W	Pathogenic(Last reviewed: May 10, 2012)	classified by single submitter	5	1260509	0.858
BRAF	P15056	G464V	Pathogenic(Last reviewed: May 3, 2011)	classified by multiple submitters	7	140781617	0.979
SGCG|SACS	Q13326	E263K	Pathogenic(Last reviewed: May 30, 2013)	classified by multiple submitters	13	23324452	0.693
BRAF	P15056	L597V	Pathogenic(Last reviewed: Nov 14, 2014)	classified by multiple submitters	7	140753346	0.675
RB1	P06400	R661W	Pathogenic(Last reviewed: Nov 18, 2013)	classified by multiple submitters	13	48459708	0.986
NRAS	P01111	G12D	Pathogenic(Last reviewed: Nov 24, 2014)	classified by multiple submitters	1	114716126	0.966
KRAS	P01116	V14I	Pathogenic(Last reviewed: Oct 10, 2014)	classified by multiple submitters	12	25245345	0.614
FZD6	O60353	R511C	Pathogenic(Last reviewed: Oct 3, 2012)	classified by multiple submitters	8	103328406	0.983
BRAF	P15056	V600E	Pathogenic(Last reviewed: Oct 3, 2014)	classified by multiple submitters	7	140753336	0.928
FGFR3	P22607	K650Q	Pathogenic(Last reviewed: Sep 22, 2014)	classified by multiple submitters	4	1806162	0.9
TP53	P04637	R273H	Pathogenic(Last reviewed: Sep 29, 2014)	classified by multiple submitters	17	7673802	0.85
EGFR|EGFR-AS1	P00533	T790M	Pathogenic/Likely pathogenic, drug response(Last reviewed: Nov 11, 2014)	classified by multiple submitters	7	55181378	0.932
BRCA1	P38398	R71G	Pathogenic/Likely pathogenic, not provided(Last reviewed: Nov 13, 2014)	classified by multiple submitters	17	43106457	0.749
TP53	P04637	P151T	Pathogenic/Likely pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	17	7675161	0.804
BRAF	P15056	G464E	Pathogenic/Likely pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	7	140781617	0.99
PTPN11	Q06124	E76G	Pathogenic/Likely pathogenic(Last reviewed: Aug 26, 2014)	classified by multiple submitters	12	112450407	0.934
TP53	P04637	M246V	Pathogenic/Likely pathogenic(Last reviewed: Jul 24, 2014)	classified by multiple submitters	17	7674227	0.83
KCNJ5	P48544	G151R	Pathogenic/Likely pathogenic(Last reviewed: Mar 16, 2015)	classified by multiple submitters	11	128911724	0.99
KRAS	P01116	G60V	Pathogenic/Likely pathogenic(Last reviewed: May 13, 2014)	classified by multiple submitters	12	25227345	0.913