Chromosome	Start_position	End_position	Reference	Variant	Reference_version	Gene	Amino_acid_substitution	Diseases	Pubmed_sources	PON-P2_predicted_probability_of_harmfulness
1	11169361	11169361	C	G	GRCh37	MTOR	p.R2505P	[renal carcinoma]	[24631838]	0.885
1	11174420	11174420	C	T	GRCh37	MTOR	p.E2419K	[bladder transitional cell carcinoma]	[24625776]	0.837
1	11182179	11182179	G	T	GRCh37	MTOR	p.Q2223K	[renal carcinoma]	[24622468]	0.778
1	11184573	11184573	G	T	GRCh37	MTOR	p.S2215Y	[renal carcinoma]	[24631838]	0.676
1	11187857	11187857	C	T	GRCh37	MTOR	p.E2014K	[bladder transitional cell carcinoma]	[24625776]	0.843
1	11217299	11217299	A	G	GRCh37	MTOR	p.L1460P	[renal carcinoma]	[24631838]	0.897
1	16464489	16464489	C	G	GRCh37	EPHA2	p.G391R	[lung squamous cell carcinoma]	[20360610]	0.462
1	36933434	36933434	G	A	GRCh37	CSF3R	p.T618I	[chronic myeloid leukemia	NA	0.737
1	36933444	36933444	T	C	GRCh37	CSF3R	p.T615A	[chronic myeloid leukemia]	[23656643]	0.316
1	43815009	43815009	G	T	GRCh37	MPL	p.W515L	[hematologic cancer]	[16834459]	0.198
1	65312382	65312382	G	A	GRCh37	JAK1	p.S646F	[lymphoblastic leukemia]	[22955920]	0.622
1	115256528	115256528	T	A	GRCh37	NRAS	p.Q61H	[melanoma	NA	0.614
1	115256529	115256529	T	A	GRCh37	NRAS	p.Q61L	[non-small cell lung carcinoma	NA	0.617
1	115256529	115256529	T	C	GRCh37	NRAS	p.Q61R	[thyroid cancer	NA	0.762
1	115256529	115256529	T	G	GRCh37	NRAS	p.Q61P	[non-small cell lung carcinoma	NA	0.714
1	115256530	115256530	G	C	GRCh37	NRAS	p.Q61E	[melanoma]	[8120410	0.621
1	115256530	115256530	G	T	GRCh37	NRAS	p.Q61K	[thyroid cancer	NA	0.386
1	115258744	115258744	C	A	GRCh37	NRAS	p.G13V	[melanoma	NA	0.942
1	115258744	115258744	C	G	GRCh37	NRAS	p.G13A	[melanoma]	[8120410	0.708
1	115258744	115258744	C	T	GRCh37	NRAS	p.G13D	[melanoma	NA	0.966
1	115258745	115258745	C	A	GRCh37	NRAS	p.G13C	[melanoma]	[8120410	0.9
1	115258745	115258745	C	G	GRCh37	NRAS	p.G13R	[melanoma]	[8120410	0.952
1	115258747	115258747	C	A	GRCh37	NRAS	p.G12V	[melanoma	NA	0.942
1	115258747	115258747	C	G	GRCh37	NRAS	p.G12A	[non-small cell lung carcinoma	NA	0.708
6	152332832	152332832	G	C	GRCh37	ESR1	p.E380Q	[breast cancer]	[24398047	0.883
1	115258747	115258747	C	T	GRCh37	NRAS	p.G12D	[non-small cell lung carcinoma	NA	0.966
1	115258748	115258748	C	A	GRCh37	NRAS	p.G12C	[non-small cell lung carcinoma	NA	0.9
1	115258748	115258748	C	G	GRCh37	NRAS	p.G12R	[non-small cell lung carcinoma	NA	0.952
1	115258748	115258748	C	T	GRCh37	NRAS	p.G12S	[non-small cell lung carcinoma	NA	0.878
1	162724415	162724415	C	G	GRCh37	DDR2	p.L63V	[lung squamous cell carcinoma]	[22328973]	0.785
1	162729630	162729630	T	G	GRCh37	DDR2	p.L239R	[lung squamous cell carcinoma]	[22328973]	0.973
1	162729671	162729671	G	T	GRCh37	DDR2	p.G253C	[lung squamous cell carcinoma]	[22328973]	0.919
1	162741822	162741822	G	A	GRCh37	DDR2	p.G505S	[lung squamous cell carcinoma]	[22328973]	0.377
1	162745497	162745497	A	T	GRCh37	DDR2	p.I638F	[lung squamous cell carcinoma]	[22328973]	0.81
1	162748390	162748390	T	A	GRCh37	DDR2	p.S768R	[squamous cell carcinoma]	[23932362	0.594
1	162748407	162748407	G	T	GRCh37	DDR2	p.G774V	[lung squamous cell carcinoma]	[22328973]	0.921
2	25457242	25457242	C	A	GRCh37	DNMT3A	p.R882L	[acute myeloid leukemia]	[22160010	0.717
2	25457242	25457242	C	G	GRCh37	DNMT3A	p.R882P	[acute myeloid leukemia]	[21067377	0.867
2	25457242	25457242	C	T	GRCh37	DNMT3A	p.R882H	[acute myeloid leukemia]	[21067377	0.498
2	25457243	25457243	G	A	GRCh37	DNMT3A	p.R882C	[acute myeloid leukemia]	[21067377	0.877
2	25457243	25457243	G	C	GRCh37	DNMT3A	p.R882G	[acute myeloid leukemia]	[22160010	0.643
2	25457243	25457243	G	T	GRCh37	DNMT3A	p.R882S	[acute myeloid leukemia]	[21067377	0.793
2	29432655	29432655	T	G	GRCh37	ALK	p.Y1278S	[neuroblastoma]	[22072639	0.628
2	29432664	29432664	C	T	GRCh37	ALK	p.R1275Q	[neuroblastoma	NA	0.949
2	29432682	29432682	C	G	GRCh37	ALK	p.G1269A	[lung adenocarcinoma]	[22277784	0.892
2	29436858	29436858	G	C	GRCh37	ALK	p.F1245L	[neuroblastoma]	[22072639	0.844
2	29436859	29436859	A	C	GRCh37	ALK	p.F1245C	[neuroblastoma]	[21838707	0.92
2	29436860	29436860	A	C	GRCh37	ALK	p.F1245V	[neuroblastoma]	[22072639	0.903
2	29436920	29436920	C	T	GRCh37	ALK	p.D1225N	[rhabdomyosarcoma]	[22184391]	0.945
2	29443600	29443600	G	T	GRCh37	ALK	p.S1206Y	[lung adenocarcinoma]	[22277784	0.734
2	29443613	29443613	C	T	GRCh37	ALK	p.G1202R	[lung adenocarcinoma]	[22277784]	0.948
2	29443631	29443631	G	T	GRCh37	ALK	p.L1196M	[lung adenocarcinoma]	[22277784	0.759
2	29443642	29443642	C	G	GRCh37	ALK	p.R1192P	[brain cancer]	[22072639]	0.939
2	29443695	29443695	G	C	GRCh37	ALK	p.F1174L	[lung adenocarcinoma]	[22277784	0.853
2	29443696	29443696	A	C	GRCh37	ALK	p.F1174C	[neuroblastoma]	[22072639	0.918
2	29443697	29443697	A	C	GRCh37	ALK	p.F1174V	[neuroblastoma]	[22072639	0.903
2	29443697	29443697	A	T	GRCh37	ALK	p.F1174I	[neuroblastoma]	[22072639	0.923
2	29445213	29445213	A	T	GRCh37	ALK	p.I1171N	[neuroblastoma]	[21838707	0.919
2	29445270	29445270	A	C	GRCh37	ALK	p.L1152R	[lung adenocarcinoma]	[22277784]	0.968
2	29445273	29445273	G	A	GRCh37	ALK	p.T1151M	[neuroblastoma]	[22072639	0.928
2	29445450	29445450	C	G	GRCh37	ALK	p.G1128A	[brain cancer]	[22072639]	0.895
2	29446296	29446296	C	T	GRCh37	ALK	p.D1091N	[neuroblastoma]	[22072639	0.763
2	198266832	198266832	T	A	GRCh37	SF3B1	p.K700N	[acute myeloid leukemia]	[23395771]	0.555
2	198266833	198266833	T	A	GRCh37	SF3B1	p.K700I	[acute myeloid leukemia]	[23395771]	0.871
2	198266833	198266833	T	C	GRCh37	SF3B1	p.K700R	[acute myeloid leukemia]	[23395771]	0.46
2	198266833	198266833	T	G	GRCh37	SF3B1	p.K700T	[acute myeloid leukemia]	[23395771]	0.666
2	198266834	198266834	T	C	GRCh37	SF3B1	p.K700E	[acute myeloid leukemia]	[23395771]	0.755
2	198266834	198266834	T	G	GRCh37	SF3B1	p.K700Q	[acute myeloid leukemia]	[23395771]	0.787
2	198267359	198267359	C	A	GRCh37	SF3B1	p.K666N	[acute myeloid leukemia]	[23395771]	0.646
2	198267360	198267360	T	C	GRCh37	SF3B1	p.K666R	[acute myeloid leukemia]	[23634996]	0.785
2	198267360	198267360	T	G	GRCh37	SF3B1	p.K666T	[acute myeloid leukemia]	[23634996]	0.762
2	198267361	198267361	T	C	GRCh37	SF3B1	p.K666E	[acute myeloid leukemia]	[23634996]	0.797
2	209113112	209113112	C	A	GRCh37	IDH1	p.R132L	[acute myeloid leukemia]	[22160010	0.964
2	209113112	209113112	C	G	GRCh37	IDH1	p.R132P	[acute myeloid leukemia]	[22160010	0.908
2	209113112	209113112	C	T	GRCh37	IDH1	p.R132H	[brain cancer	NA	0.932
2	209113113	209113113	G	A	GRCh37	IDH1	p.R132C	[acute myeloid leukemia]	[19657110	0.974
2	209113113	209113113	G	C	GRCh37	IDH1	p.R132G	[acute myeloid leukemia]	[22160010	0.942
2	209113113	209113113	G	T	GRCh37	IDH1	p.R132S	[acute myeloid leukemia]	[19657110	0.939
2	212295699	212295699	C	T	GRCh37	ERBB4	p.E872K	[melanoma]	[19718025]	0.904
2	212537975	212537975	G	A	GRCh37	ERBB4	p.R544W	[melanoma]	[19718025]	0.936
2	212537981	212537981	C	T	GRCh37	ERBB4	p.E542K	[melanoma]	[19718025]	0.902
2	212566827	212566827	C	T	GRCh37	ERBB4	p.E452K	[melanoma]	[19718025]	0.715
2	212570064	212570064	G	A	GRCh37	ERBB4	p.R393W	[melanoma]	[19718025]	0.733
2	212578308	212578308	C	T	GRCh37	ERBB4	p.E317K	[melanoma]	[19718025]	0.657
3	12641195	12641195	C	G	GRCh37	RAF1	p.W388S	[melanoma]	[23737487]	0.869
3	12645700	12645700	A	G	GRCh37	RAF1	p.S257P	[melanoma]	[23737487]	0.866
3	38182641	38182641	T	C	GRCh37	MYD88	p.L273P	[lymphoma]	[21179087]	0.911
3	41266113	41266113	C	A	GRCh37	CTNNB1	p.S37Y	[melanoma]	[11950921	0.956
3	41266113	41266113	C	T	GRCh37	CTNNB1	p.S37F	[melanoma]	[11950921	0.943
3	41266136	41266136	T	C	GRCh37	CTNNB1	p.S45P	[melanoma]	[11950921	0.897
3	41266137	41266137	C	A	GRCh37	CTNNB1	p.S45Y	[melanoma]	[11950921	0.956
3	41266137	41266137	C	T	GRCh37	CTNNB1	p.S45F	[melanoma]	[11950921	0.943
3	128200113	128200113	G	A	GRCh37	GATA2	p.R398W	[acute myeloid leukemia]	[22147895	0.982
3	128200744	128200744	G	A	GRCh37	GATA2	p.T354M	[acute myeloid leukemia]	[22147895	0.914
3	178936082	178936082	G	A	GRCh37	PIK3CA	p.E542K	[ovarian cancer	NA	0.739
3	178936091	178936091	G	A	GRCh37	PIK3CA	p.E545K	[ovarian cancer	NA	0.922
3	178936091	178936091	G	C	GRCh37	PIK3CA	p.E545Q	[non-small cell lung carcinoma	NA	0.82
3	178936092	178936092	A	C	GRCh37	PIK3CA	p.E545A	[ovarian cancer	NA	0.864
3	178936092	178936092	A	G	GRCh37	PIK3CA	p.E545G	[colorectal cancer	NA	0.876
3	178936092	178936092	A	T	GRCh37	PIK3CA	p.E545V	[colorectal cancer	NA	0.843
3	178936094	178936094	C	A	GRCh37	PIK3CA	p.Q546K	[ovarian cancer	NA	0.634
3	178936094	178936094	C	G	GRCh37	PIK3CA	p.Q546E	[colorectal cancer	NA	0.684
3	178936095	178936095	A	C	GRCh37	PIK3CA	p.Q546P	[colorectal cancer	NA	0.775
3	178936095	178936095	A	G	GRCh37	PIK3CA	p.Q546R	[colorectal cancer	NA	0.825
9	5073770	5073770	G	T	GRCh37	JAK2	p.V617F	[myelofibrosis	NA	0.865
3	178936095	178936095	A	T	GRCh37	PIK3CA	p.Q546L	[breast cancer]	[20453058	0.839
3	178936103	178936103	G	A	GRCh37	PIK3CA	p.D549N	[colorectal cancer	NA	0.647
3	178952085	178952085	A	G	GRCh37	PIK3CA	p.H1047R	[ovarian cancer	NA	0.802
3	178952085	178952085	A	T	GRCh37	PIK3CA	p.H1047L	[ovarian cancer	NA	0.695
4	1806099	1806099	A	G	GRCh37	FGFR3	p.Y375C	[myeloma]	[19331127	0.919
4	1807488	1807488	G	A	GRCh37	FGFR3	p.V555M	[myeloma]	[22869148]	0.898
4	55141036	55141036	T	A	GRCh37	PDGFRA	p.V561D	[gastrointestinal stromal tumor]	[14645423	0.92
4	55141083	55141083	C	T	GRCh37	PDGFRA	p.P577S	[melanoma]	[24132921]	0.947
4	55144144	55144144	T	C	GRCh37	PDGFRA	p.V658A	[melanoma]	[24132921]	0.524
4	55144148	55144148	C	A	GRCh37	PDGFRA	p.N659K	[gastrointestinal stromal tumor]	[14645423	0.482
4	55152090	55152090	G	A	GRCh37	PDGFRA	p.R841K	[melanoma]	[24132921]	0.286
4	55152093	55152093	A	T	GRCh37	PDGFRA	p.D842V	[gastrointestinal stromal tumor]	[14645423	0.262
4	55152101	55152101	C	T	GRCh37	PDGFRA	p.H845Y	[melanoma]	[24132921]	0.211
4	55152126	55152126	G	A	GRCh37	PDGFRA	p.G853D	[melanoma]	[24132921]	0.154
4	55592144	55592144	G	A	GRCh37	KIT	p.E490K	[thymic carcinoma]	[22357254	0.76
4	55592186	55592186	T	C	GRCh37	KIT	p.F504L	[melanoma]	[21131919]	0.726
4	55593584	55593584	A	C	GRCh37	KIT	p.K550N	[melanoma]	[24661573	0.691
4	55593591	55593591	T	A	GRCh37	KIT	p.Y553N	[thymic carcinoma	NA	0.9
4	55593603	55593603	T	A	GRCh37	KIT	p.W557R	[melanoma]	[15790786	0.906
4	55593608	55593608	G	C	GRCh37	KIT	p.K558N	[melanoma]	[22160160]	0.694
4	55593609	55593609	G	A	GRCh37	KIT	p.V559I	[gastrointestinal stromal tumor]	[23582185	0.812
4	55593610	55593610	T	A	GRCh37	KIT	p.V559D	[melanoma	NA	0.914
4	55593610	55593610	T	C	GRCh37	KIT	p.V559A	[thymic carcinoma	NA	0.914
4	55593610	55593610	T	G	GRCh37	KIT	p.V559G	[melanoma]	[24661573	0.581
4	55593613	55593613	T	A	GRCh37	KIT	p.V560D	[melanoma]	[18936790]	0.884
4	55593613	55593613	T	C	GRCh37	KIT	p.V560A	[melanoma]	[18936790]	0.815
4	55593613	55593613	T	G	GRCh37	KIT	p.V560G	[melanoma]	[18936790]	0.698
4	55593630	55593630	A	G	GRCh37	KIT	p.N566D	[melanoma]	[24661573	0.722
4	55593640	55593640	T	G	GRCh37	KIT	p.V569G	[melanoma]	[24661573	0.543
4	55593661	55593661	T	C	GRCh37	KIT	p.L576P	[thymic carcinoma	NA	0.966
4	55594221	55594221	A	G	GRCh37	KIT	p.K642E	[melanoma]	[15790786	0.929
4	55594258	55594258	T	A	GRCh37	KIT	p.V654E	[melanoma]	[22932406]	0.803
4	55594258	55594258	T	C	GRCh37	KIT	p.V654A	[melanoma	NA	0.893
4	55594261	55594261	A	G	GRCh37	KIT	p.N655S	[melanoma]	[24661573	0.855
4	55594262	55594262	T	A	GRCh37	KIT	p.N655K	[melanoma]	[24661573	0.876
4	55595519	55595519	C	T	GRCh37	KIT	p.T670I	[gastrointestinal stromal tumor]	[24687822	0.928
4	55595599	55595599	C	T	GRCh37	KIT	p.H697Y	[thymic carcinoma]	[19861435]	0.533
4	55599320	55599320	G	C	GRCh37	KIT	p.D816H	[melanoma	NA	0.915
4	55599320	55599320	G	T	GRCh37	KIT	p.D816Y	[melanoma	NA	0.912
4	55599321	55599321	A	T	GRCh37	KIT	p.D816V	[gastrointestinal stromal tumor	NA	0.902
4	55599332	55599332	G	C	GRCh37	KIT	p.D820H	[melanoma]	[15790786	0.915
4	55599332	55599332	G	T	GRCh37	KIT	p.D820Y	[melanoma]	[20088873	0.912
4	55599333	55599333	A	T	GRCh37	KIT	p.D820V	[systemic mastocytosis]	[18559612]	0.902
4	55599334	55599334	T	A	GRCh37	KIT	p.D820E	[thymic carcinoma]	[19461405	0.798
4	55599339	55599339	A	T	GRCh37	KIT	p.N822I	[melanoma	NA	0.871
4	55599340	55599340	T	A	GRCh37	KIT	p.N822K	[melanoma	NA	0.767
4	55599341	55599341	T	G	GRCh37	KIT	p.Y823D	[gastrointestinal stromal tumor]	[23582185	0.921
4	55602664	55602664	G	C	GRCh37	KIT	p.A829P	[melanoma	NA	0.799
5	35873597	35873597	A	T	GRCh37	IL7R	p.S185C	[lymphoblastic leukemia]	[22897847	0.261
5	149441328	149441328	A	C	GRCh37	CSF1R	p.Y571D	[hematologic cancer]	[18971950]	0.95
5	176522416	176522416	C	A	GRCh37	FGFR4	p.N535K	[rhabdomyosarcoma]	[24124571]	0.88
5	176522552	176522552	T	A	GRCh37	FGFR4	p.V550E	[rhabdomyosarcoma]	[24124571]	0.969
6	117638347	117638347	C	T	GRCh37	ROS1	p.G2032R	[lung adenocarcinoma]	[23724914]	0.55
6	152415537	152415537	T	C	GRCh37	ESR1	p.S463P	[progesterone-receptor positive breast cancer]	[24185512]	0.871
6	152419914	152419914	T	A	GRCh37	ESR1	p.V534E	[progesterone-receptor positive breast cancer]	[24185512]	0.748
6	152419917	152419917	C	A	GRCh37	ESR1	p.P535H	[progesterone-receptor positive breast cancer]	[24185512]	0.916
6	152419920	152419920	T	G	GRCh37	ESR1	p.L536R	[progesterone-receptor positive breast cancer]	[24185512	0.94
6	152419922	152419922	T	A	GRCh37	ESR1	p.Y537N	[progesterone-receptor positive breast cancer]	[24185512	0.944
6	152419923	152419923	A	C	GRCh37	ESR1	p.Y537S	[progesterone-receptor positive breast cancer]	[24185512	0.687
6	152419923	152419923	A	G	GRCh37	ESR1	p.Y537C	[progesterone-receptor positive breast cancer]	[24185512	0.955
6	152419926	152419926	A	G	GRCh37	ESR1	p.D538G	[progesterone-receptor positive breast cancer]	[24185512	0.902
7	55211080	55211080	G	A	GRCh37	EGFR	p.R108K	[brain cancer]	[17177598]	0.939
7	55221743	55221743	A	C	GRCh37	EGFR	p.T263P	[brain cancer]	[17177598]	0.713
7	55221822	55221822	C	T	GRCh37	EGFR	p.A289V	[brain cancer]	[17177598]	0.931
7	55233043	55233043	G	T	GRCh37	EGFR	p.G598V	[brain cancer]	[17177598]	0.938
7	55228007	55228007	A	G	GRCh37	EGFR	p.S492G	[colorectal cancer]	[22270724]	0.55
7	55231430	55231430	C	T	GRCh37	EGFR	p.P546S	[cancer]	[23578570]	0.939
7	55241620	55241620	G	A	GRCh37	EGFR	p.E690K	[endometrial cancer]	[22885469]	0.946
7	55241707	55241707	G	A	GRCh37	EGFR	p.G719S	[non-small cell lung carcinoma]	[15118073	0.954
7	55241707	55241707	G	T	GRCh37	EGFR	p.G719C	[non-small cell lung carcinoma]	[15118073	0.953
7	55241708	55241708	G	A	GRCh37	EGFR	p.G719D	[lung squamous cell carcinoma]	[22753918	0.976
7	55241708	55241708	G	C	GRCh37	EGFR	p.G719A	[non-small cell lung carcinoma]	[15118073	0.941
7	55242470	55242470	T	C	GRCh37	EGFR	p.L747S	[lung squamous cell carcinoma]	[22753918	0.928
7	55242487	55242487	C	T	GRCh37	EGFR	p.P753S	[cancer]	[24934779]	0.884
7	55249005	55249005	G	T	GRCh37	EGFR	p.S768I	[lung squamous cell carcinoma]	[22753918	0.94
7	55249071	55249071	C	T	GRCh37	EGFR	p.T790M	[non-small cell lung carcinoma]	[15118073	0.932
7	55259469	55259469	G	A	GRCh37	EGFR	p.V843I	[cancer]	[21274259]	0.7
7	55259515	55259515	T	G	GRCh37	EGFR	p.L858R	[non-small cell lung carcinoma]	[15118073	0.979
7	55259524	55259524	T	A	GRCh37	EGFR	p.L861Q	[non-small cell lung carcinoma]	[15118073	0.947
7	55259524	55259524	T	C	GRCh37	EGFR	p.L861P	[lung squamous cell carcinoma]	[22753918	0.971
7	55259524	55259524	T	G	GRCh37	EGFR	p.L861R	[lung squamous cell carcinoma]	[22753918	0.979
7	116411923	116411923	C	T	GRCh37	MET	p.R988C	[cancer]	[17483355]	0.841
7	116411990	116411990	C	T	GRCh37	MET	p.T1010I	[cancer]	[17483355]	0.961
7	116417457	116417457	G	A	GRCh37	MET	p.V1110I	[cancer]	[17483355]	0.78
7	116417464	116417464	A	G	GRCh37	MET	p.H1112R	[renal carcinoma]	[23213094]	0.945
7	116423414	116423414	A	G	GRCh37	MET	p.Y1248C	[cancer]	[17483355]	0.92
7	116423428	116423428	T	G	GRCh37	MET	p.Y1253D	[cancer]	[17483355]	0.914
7	116423474	116423474	T	C	GRCh37	MET	p.M1268T	[renal carcinoma]	[23610116]	0.882
7	116423475	116423475	G	A	GRCh37	MET	p.M1268I	[cancer]	[17483355]	0.837
7	128849189	128849189	G	C	GRCh37	SMO	p.D473H	[medulloblastoma	NA	0.809
7	148508728	148508728	A	G	GRCh37	EZH2	p.Y646H	[lymphoma]	[23023262]	0.76
7	148508728	148508728	A	T	GRCh37	EZH2	p.Y646N	[lymphoma]	[23023262]	0.88
7	148508727	148508727	T	A	GRCh37	EZH2	p.Y646F	[lymphoma]	[23023262	0.436
7	148508727	148508727	T	G	GRCh37	EZH2	p.Y646S	[lymphoma]	[23023262]	0.748
7	148506467	148506467	G	C	GRCh37	EZH2	p.A682G	[lymphoma]	[23023262]	0.783
7	140453133	140453133	T	C	GRCh37	BRAF	p.K601R	[melanoma]	[23248257]	0.813
7	140453134	140453134	T	C	GRCh37	BRAF	p.K601E	[melanoma]	[14679157	0.944
7	140453136	140453136	A	C	GRCh37	BRAF	p.V600G	[melanoma]	[12068308	0.663
7	140453136	140453136	A	T	GRCh37	BRAF	p.V600E	[myeloma	NA	0.928
7	140453137	140453137	C	A	GRCh37	BRAF	p.V600L	[melanoma]	[21750866	0.579
7	140453137	140453137	C	T	GRCh37	BRAF	p.V600M	[melanoma]	[12460918	0.721
7	140453145	140453145	A	C	GRCh37	BRAF	p.L597R	[ovarian cancer	NA	0.929
7	140453145	140453145	A	T	GRCh37	BRAF	p.L597Q	[melanoma]	[12460918	0.772
7	140453146	140453146	G	C	GRCh37	BRAF	p.L597V	[melanoma	NA	0.675
7	140453149	140453149	C	G	GRCh37	BRAF	p.G596R	[colorectal cancer]	[19537845	0.858
7	140453153	140453153	A	C	GRCh37	BRAF	p.D594E	[melanoma]	[12068308	0.835
7	140453154	140453154	T	A	GRCh37	BRAF	p.D594V	[melanoma	NA	0.898
7	140453154	140453154	T	C	GRCh37	BRAF	p.D594G	[melanoma	NA	0.752
7	140453154	140453154	T	G	GRCh37	BRAF	p.D594A	[melanoma]	[2872605]	0.825
7	140453155	140453155	C	G	GRCh37	BRAF	p.D594H	[melanoma]	[12068308	0.842
7	140453155	140453155	C	T	GRCh37	BRAF	p.D594N	[melanoma]	[12068308	0.79
7	140481393	140481393	T	C	GRCh37	BRAF	p.Y472C	[lung cancer]	[12460918	0.892
7	140481402	140481402	C	G	GRCh37	BRAF	p.G469A	[lung adenocarcinoma	NA	0.601
7	140481402	140481402	C	T	GRCh37	BRAF	p.G469E	[melanoma	NA	0.943
7	140481411	140481411	C	A	GRCh37	BRAF	p.G466V	[lung cancer	NA	0.887
9	5078360	5078360	A	G	GRCh37	JAK2	p.R683G	[lymphoblastic leukemia]	[19470474	0.929
9	5078361	5078361	G	C	GRCh37	JAK2	p.R683T	[lymphoblastic leukemia]	[19470474	0.916
9	5078362	5078362	A	C	GRCh37	JAK2	p.R683S	[lymphoblastic leukemia]	[19470474	0.93
9	80409488	80409488	T	A	GRCh37	GNAQ	p.Q209L	[melanoma]	[18719078	0.916
9	80409488	80409488	T	C	GRCh37	GNAQ	p.Q209R	[melanoma]	[18719078	0.836
9	80409488	80409488	T	G	GRCh37	GNAQ	p.Q209P	[melanoma]	[18719078	0.833
9	133738306	133738306	G	A	GRCh37	ABL1	p.E255K	[chronic myeloid leukemia]	[21562040]	0.972
9	133738357	133738357	T	C	GRCh37	ABL1	p.Y272H	[chronic myeloid leukemia]	[21562040]	0.968
9	133747588	133747588	G	C	GRCh37	ABL1	p.V318L	[chronic myeloid leukemia]	[21562040]	0.908
9	133748282	133748282	A	G	GRCh37	ABL1	p.T334A	[chronic myeloid leukemia]	[21562040]	0.927
9	133748283	133748283	C	T	GRCh37	ABL1	p.T334I	[chronic myeloid leukemia	NA	0.958
9	133748288	133748288	T	A	GRCh37	ABL1	p.F336I	[chronic myeloid leukemia]	[21562040]	0.972
9	133748288	133748288	T	G	GRCh37	ABL1	p.F336V	[chronic myeloid leukemia]	[21562040]	0.955
9	133748289	133748289	T	G	GRCh37	ABL1	p.F336C	[chronic myeloid leukemia]	[21562040]	0.977
9	133748290	133748290	C	A	GRCh37	ABL1	p.F336L	[chronic myeloid leukemia]	[21562040]	0.964
9	133748414	133748414	T	A	GRCh37	ABL1	p.F378I	[chronic myeloid leukemia]	[21562040]	0.969
9	133748414	133748414	T	C	GRCh37	ABL1	p.F378L	[chronic myeloid leukemia]	[21562040]	0.954
9	133748415	133748415	T	G	GRCh37	ABL1	p.F378C	[chronic myeloid leukemia]	[21562040]	0.978
10	43609950	43609950	C	G	GRCh37	RET	p.C634W	[thyroid cancer]	[20065189	0.856
10	43617416	43617416	T	C	GRCh37	RET	p.M918T	[thyroid cancer]	[9681850	0.964
10	89692904	89692904	C	G	GRCh37	PTEN	p.R130G	[ovarian cancer]	[18767981	0.912
10	89692905	89692905	G	A	GRCh37	PTEN	p.R130Q	[ovarian cancer]	[18767981	0.949
10	89692993	89692993	G	T	GRCh37	PTEN	p.R159S	[colorectal cancer	NA	0.856
10	123247516	123247516	T	C	GRCh37	FGFR2	p.K660E	[endometrial cancer]	[23908597]	0.946
10	123256060	123256060	A	T	GRCh37	FGFR2	p.L618M	[endometrial cancer]	[23908597]	0.694
10	123256215	123256215	T	C	GRCh37	FGFR2	p.E566G	[endometrial cancer]	[23908597]	0.907
10	123256219	123256219	C	T	GRCh37	FGFR2	p.V565I	[endometrial cancer]	[23908597]	0.805
10	123258034	123258034	A	C	GRCh37	FGFR2	p.N550K	[endometrial cancer]	[18552176	0.895
10	123258036	123258036	T	G	GRCh37	FGFR2	p.N550H	[endometrial cancer]	[23908597]	0.921
10	123258042	123258042	T	C	GRCh37	FGFR2	p.I548V	[endometrial cancer]	[23908597]	0.798
10	123258070	123258070	C	A	GRCh37	FGFR2	p.M538I	[endometrial cancer]	[23908597]	0.93
10	123258076	123258076	C	A	GRCh37	FGFR2	p.M536I	[endometrial cancer]	[23908597]	0.93
10	123279677	123279677	G	C	GRCh37	FGFR2	p.S252W	[endometrial cancer]	[18552176	0.827
10	123278324	123278324	G	C	GRCh37	FGFR2	p.S320C	[lung squamous cell carcinoma]	[23786770]	0.729
10	123279562	123279562	C	G	GRCh37	FGFR2	p.W290C	[lung squamous cell carcinoma]	[23786770]	0.984
10	123279674	123279674	G	C	GRCh37	FGFR2	p.P253R	[cancer]	[23786770]	0.911
11	533874	533874	T	C	GRCh37	HRAS	p.Q61R	[thyroid cancer]	[17384584	0.817
11	534286	534286	C	A	GRCh37	HRAS	p.G13C	[thyroid cancer]	[17384584	0.975
11	534286	534286	C	G	GRCh37	HRAS	p.G13R	[thyroid cancer]	[17384584	0.974
11	534288	534288	C	A	GRCh37	HRAS	p.G12V	[thyroid cancer]	[17384584	0.973
11	534289	534289	C	G	GRCh37	HRAS	p.G12R	[thyroid cancer]	[17384584	0.967
11	119148891	119148891	T	C	GRCh37	CBL	p.Y371H	[hematologic cancer]	[23696637]	0.833
11	119148930	119148930	T	C	GRCh37	CBL	p.C384R	[hematologic cancer]	[23696637]	0.917
12	25378561	25378561	G	A	GRCh37	KRAS	p.A146V	[thyroid cancer	NA	0.863
12	25378562	25378562	C	G	GRCh37	KRAS	p.A146P	[colorectal cancer]	[18316791	0.832
12	25378562	25378562	C	T	GRCh37	KRAS	p.A146T	[colorectal cancer]	[18316791	0.893
12	25378647	25378647	T	A	GRCh37	KRAS	p.K117N	[colorectal cancer]	[18316791	0.728
12	25380275	25380275	T	A	GRCh37	KRAS	p.Q61H	[non-small cell lung carcinoma	NA	0.824
12	25380276	25380276	T	A	GRCh37	KRAS	p.Q61L	[thyroid cancer	NA	0.769
12	25380276	25380276	T	C	GRCh37	KRAS	p.Q61R	[thyroid cancer	NA	0.857
12	25380276	25380276	T	G	GRCh37	KRAS	p.Q61P	[thyroid cancer]	[17384584	0.877
12	25380277	25380277	G	T	GRCh37	KRAS	p.Q61K	[thyroid cancer	NA	0.636
12	25398281	25398281	C	A	GRCh37	KRAS	p.G13V	[colorectal cancer]	[18316791	0.656
12	25398284	25398284	C	A	GRCh37	KRAS	p.G12V	[thyroid cancer	NA	0.719
12	25398281	25398281	C	G	GRCh37	KRAS	p.G13A	[non-small cell lung carcinoma	NA	0.657
12	25398281	25398281	C	T	GRCh37	KRAS	p.G13D	[thyroid cancer	NA	0.742
12	25398282	25398282	C	A	GRCh37	KRAS	p.G13C	[non-small cell lung carcinoma	NA	0.59
12	25398282	25398282	C	G	GRCh37	KRAS	p.G13R	[thyroid cancer	NA	0.601
12	25398282	25398282	C	T	GRCh37	KRAS	p.G13S	[thyroid cancer	NA	0.743
12	25398284	25398284	C	G	GRCh37	KRAS	p.G12A	[ovarian cancer	NA	0.537
12	25398284	25398284	C	T	GRCh37	KRAS	p.G12D	[thyroid cancer	NA	0.747
12	25398285	25398285	C	A	GRCh37	KRAS	p.G12C	[thyroid cancer	NA	0.721
12	25398285	25398285	C	G	GRCh37	KRAS	p.G12R	[thyroid cancer	NA	0.735
13	28602340	28602340	G	C	GRCh37	FLT3	p.N676K	[acute myeloid leukemia]	[23878140	0.916
12	25398285	25398285	C	T	GRCh37	KRAS	p.G12S	[thyroid cancer	NA	0.699
12	56481857	56481857	C	A	GRCh37	ERBB3	p.P262H	[cancer]	[23680147]	0.825
12	56481922	56481922	G	A	GRCh37	ERBB3	p.G284R	[stomach cancer	NA	0.943
12	56490980	56490980	A	G	GRCh37	ERBB3	p.Q809R	[cancer]	[23680147]	0.857
13	28592620	28592620	T	C	GRCh37	FLT3	p.Y842C	[acute myeloid leukemia]	[22504184	0.973
13	28592621	28592621	A	G	GRCh37	FLT3	p.Y842H	[acute myeloid leukemia]	[22504184	0.881
13	28592629	28592629	T	C	GRCh37	FLT3	p.D839G	[acute myeloid leukemia]	[15667533]	0.92
13	28592637	28592637	G	C	GRCh37	FLT3	p.I836M	[acute myeloid leukemia]	[23261068	0.672
13	28592639	28592639	T	G	GRCh37	FLT3	p.I836L	[acute myeloid leukemia]	[23261068	0.474
13	28592640	28592640	A	C	GRCh37	FLT3	p.D835E	[acute myeloid leukemia]	[23261068	0.678
13	28592641	28592641	T	A	GRCh37	FLT3	p.D835V	[acute myeloid leukemia]	[23261068	0.952
13	28592641	28592641	T	G	GRCh37	FLT3	p.D835A	[acute myeloid leukemia]	[23261068	0.857
13	28592642	28592642	C	A	GRCh37	FLT3	p.D835Y	[acute myeloid leukemia]	[23261068	0.938
13	28592642	28592642	C	G	GRCh37	FLT3	p.D835H	[acute myeloid leukemia]	[23261068	0.957
13	28592642	28592642	C	T	GRCh37	FLT3	p.D835N	[acute myeloid leukemia]	[23261068	0.837
13	28601359	28601359	A	C	GRCh37	FLT3	p.F691L	[acute myeloid leukemia]	[22504184]	0.828
13	28601373	28601373	T	A	GRCh37	FLT3	p.I687F	[acute myeloid leukemia]	[22504184	0.573
13	28602342	28602342	T	C	GRCh37	FLT3	p.N676D	[acute myeloid leukemia]	[22504184	0.774
13	28602416	28602416	T	C	GRCh37	FLT3	p.D651G	[acute myeloid leukemia]	[22504184	0.519
13	28608111	28608111	C	A	GRCh37	FLT3	p.G619C	[acute myeloid leukemia]	[22504184	0.892
14	105243048	105243048	G	T	GRCh37	AKT1	p.Q79K	[melanoma]	[24265152]	0.814
14	105246551	105246551	C	T	GRCh37	AKT1	p.E17K	[non-small cell lung carcinoma	NA	0.794
15	28505975	28505975	A	G	GRCh37	HERC2	p.L755S	[breast cancer]	[23220880]	0.668
15	28517518	28517518	G	C	GRCh37	HERC2	p.A309G	[breast cancer]	[23220880]	0.44
15	66727441	66727441	T	C	GRCh37	MAP2K1	p.F53L	[melanoma]	[22197931]	0.837
15	66727451	66727451	A	C	GRCh37	MAP2K1	p.Q56P	[non-small cell lung carcinoma	NA	0.874
15	66727453	66727453	A	G	GRCh37	MAP2K1	p.K57E	[melanoma]	[23569304]	0.668
15	66727455	66727455	G	C	GRCh37	MAP2K1	p.K57N	[melanoma]	[23444215]	0.815
15	66727483	66727483	G	A	GRCh37	MAP2K1	p.D67N	[non-small cell lung carcinoma]	[18060073	0.763
15	66729088	66729088	T	C	GRCh37	MAP2K1	p.I99T	[cancer]	[19915144]	0.875
15	66729100	66729100	T	A	GRCh37	MAP2K1	p.I103N	[cancer]	[19915144	0.825
15	66729124	66729124	T	A	GRCh37	MAP2K1	p.I111N	[cancer]	[19915144]	0.832
15	66729124	66729124	T	G	GRCh37	MAP2K1	p.I111S	[melanoma]	[22197931	0.908
15	66729148	66729148	A	C	GRCh37	MAP2K1	p.H119P	[cancer]	[19915144]	0.919
15	66729152	66729152	G	C	GRCh37	MAP2K1	p.E120D	[cancer]	[19915144]	0.829
15	66729154	66729154	G	C	GRCh37	MAP2K1	p.C121S	[melanoma]	[22197931	0.873
15	66729162	66729162	C	T	GRCh37	MAP2K1	p.P124S	[melanoma]	[22197931	0.905
15	66729163	66729163	C	T	GRCh37	MAP2K1	p.P124L	[melanoma]	[22197931	0.935
15	66729175	66729175	G	A	GRCh37	MAP2K1	p.G128D	[melanoma]	[19915144]	0.964
15	66729177	66729177	T	C	GRCh37	MAP2K1	p.F129L	[melanoma]	[19915144	0.922
15	66774131	66774131	G	A	GRCh37	MAP2K1	p.E203K	[melanoma]	[22197931	0.922
15	66774156	66774156	T	A	GRCh37	MAP2K1	p.V211D	[cancer]	[19915144]	0.884
15	66774168	66774168	T	C	GRCh37	MAP2K1	p.L215P	[cancer]	[19915144	0.932
15	66777424	66777424	C	T	GRCh37	MAP2K1	p.P264S	[melanoma]	[22197931	0.909
15	66782915	66782915	A	C	GRCh37	MAP2K1	p.N382H	[melanoma]	[22197931]	0.608
15	90631837	90631837	C	G	GRCh37	IDH2	p.R172S	[acute myeloid leukemia]	[22160010	0.971
15	90631838	90631838	C	A	GRCh37	IDH2	p.R172M	[acute myeloid leukemia]	[22160010	0.947
15	90631838	90631838	C	T	GRCh37	IDH2	p.R172K	[acute myeloid leukemia]	[22160010	0.843
15	90631934	90631934	C	A	GRCh37	IDH2	p.R140L	[acute myeloid leukemia]	[22160010	0.842
15	90631934	90631934	C	T	GRCh37	IDH2	p.R140Q	[acute myeloid leukemia]	[22160010	0.979
15	90631935	90631935	G	A	GRCh37	IDH2	p.R140W	[acute myeloid leukemia]	[22160010	0.971
16	81946260	81946260	C	T	GRCh37	PLCG2	p.R665W	[breast cancer]	[24869598]	0.958
16	81962183	81962183	A	C	GRCh37	PLCG2	p.L845F	[breast cancer]	[24869598]	0.478
17	7577120	7577120	C	T	GRCh37	TP53	p.R273H	[acute myeloid leukemia]	[24641375	0.85
17	7577121	7577121	G	A	GRCh37	TP53	p.R273C	[acute myeloid leukemia]	[24641375	0.958
17	7577535	7577535	C	G	GRCh37	TP53	p.R249T	[acute myeloid leukemia]	[24641375	0.725
17	7577536	7577536	T	A	GRCh37	TP53	p.R249W	[acute myeloid leukemia]	[24641375	0.871
17	7577538	7577538	C	T	GRCh37	TP53	p.R248Q	[acute myeloid leukemia]	[24641375	0.873
17	7578190	7578190	T	C	GRCh37	TP53	p.Y220C	[acute myeloid leukemia]	[24641375	0.957
17	7578412	7578412	A	C	GRCh37	TP53	p.V173G	[acute myeloid leukemia]	[24641375	0.722
17	7578412	7578412	A	G	GRCh37	TP53	p.V173A	[acute myeloid leukemia]	[24641375	0.801
17	37868205	37868205	G	A	GRCh37	ERBB2	p.G309E	[lung adenocarcinoma]	[22908275]	0.751
17	37868205	37868205	G	C	GRCh37	ERBB2	p.G309A	[breast cancer]	[23220880]	0.42
17	37868208	37868208	C	A	GRCh37	ERBB2	p.S310Y	[cancer]	[22908275]	0.331
17	37868208	37868208	C	T	GRCh37	ERBB2	p.S310F	[cancer]	[22908275]	0.491
17	37880261	37880261	G	C	GRCh37	ERBB2	p.D769H	[breast cancer]	[23220880	0.894
17	37880261	37880261	G	T	GRCh37	ERBB2	p.D769Y	[breast cancer]	[23220880	0.91
17	37881000	37881000	G	T	GRCh37	ERBB2	p.V777L	[breast cancer]	[23220880	0.822
17	37881332	37881332	G	A	GRCh37	ERBB2	p.V842I	[breast cancer]	[23220880	0.737
17	37881616	37881616	C	T	GRCh37	ERBB2	p.R896C	[breast cancer]	[23220880	0.614
18	48591826	48591826	A	C	GRCh37	SMAD4	p.E330A	[colorectal cancer]	[14715079	0.938
18	48591888	48591888	G	A	GRCh37	SMAD4	p.D351N	[colorectal cancer]	[14715079	0.906
18	48591888	48591888	G	C	GRCh37	SMAD4	p.D351H	[colorectal cancer]	[14715079	0.933
18	48591902	48591902	C	A	GRCh37	SMAD4	p.D355E	[colorectal cancer]	[14715079	0.827
18	48591918	48591918	C	A	GRCh37	SMAD4	p.R361S	[colorectal cancer]	[14715079	0.932
18	48591918	48591918	C	T	GRCh37	SMAD4	p.R361C	[colorectal cancer]	[14715079	0.984
18	48591919	48591919	G	A	GRCh37	SMAD4	p.R361H	[colorectal cancer]	[14715079	0.895
18	48604787	48604787	G	T	GRCh37	SMAD4	p.D537Y	[colorectal cancer]	[14715079	0.962
19	1220489	1220489	C	A	GRCh37	STK11	p.D194E	[rhabdomyosarcoma]	[21189378]	0.86
19	3118942	3118942	A	C	GRCh37	GNA11	p.Q209P	[melanoma]	[21083380	0.773
19	3118942	3118942	A	T	GRCh37	GNA11	p.Q209L	[melanoma]	[21083380	0.669
19	4110581	4110581	T	C	GRCh37	MAP2K2	p.N126D	[melanoma]	[24265153]	0.836
19	4110584	4110584	A	T	GRCh37	MAP2K2	p.C125S	[melanoma]	[24265153]	0.901
19	4117541	4117541	T	G	GRCh37	MAP2K2	p.Q60P	[melanoma]	[24265154]	0.888
19	4117584	4117584	G	A	GRCh37	MAP2K2	p.L46F	[melanoma]	[24265153]	0.897
19	4117617	4117617	C	T	GRCh37	MAP2K2	p.V35M	[melanoma]	[24265153]	0.717
19	17945969	17945969	C	T	GRCh37	JAK3	p.R657Q	[megakaryocytic leukemia]	[18397343]	0.845
19	17949138	17949138	C	A	GRCh37	JAK3	p.Q501H	[megakaryocytic leukemia]	[18397343]	0.591
19	17954634	17954634	A	G	GRCh37	JAK3	p.I87T	[megakaryocytic leukemia]	[18397343]	0.693
19	18278061	18278061	A	G	GRCh37	PIK3R2	p.N561D	[endometrial cancer]	[21984976]	0.815
20	57484420	57484420	C	T	GRCh37	GNAS	p.R202C	[cancer]	[21835143]	0.781
20	57484421	57484421	G	A	GRCh37	GNAS	p.R202H	[cancer]	[21835143]	0.683
20	57484421	57484421	G	T	GRCh37	GNAS	p.R202L	[cancer]	[21835143]	0.668
21	36252876	36252876	C	A	GRCh37	RUNX1	p.R162S	[acute myeloid leukemia]	[24659740	0.929
21	36252877	36252877	C	T	GRCh37	RUNX1	p.R162K	[acute myeloid leukemia]	[24659740	0.763
21	36252878	36252878	T	C	GRCh37	RUNX1	p.R162G	[acute myeloid leukemia]	[24659740	0.944
21	44514777	44514777	T	C	GRCh37	U2AF1	p.Q157R	[acute myeloid leukemia]	[22158538]	0.76
21	44514777	44514777	T	G	GRCh37	U2AF1	p.Q157P	[acute myeloid leukemia]	[22158538]	0.826
21	44524456	44524456	G	A	GRCh37	U2AF1	p.S34F	[acute myeloid leukemia]	[22158538	0.821
21	44524456	44524456	G	T	GRCh37	U2AF1	p.S34Y	[acute myeloid leukemia]	[22158538	0.491
X	1314966	1314966	A	C	GRCh37	CRLF2	p.F232C	[lymphoblastic leukemia]	[19907440	0.041
X	47426121	47426121	C	G	GRCh37	ARAF	p.S214C	[lung adenocarcinoma]	[24569458]	0.781
X	100611164	100611164	C	G	GRCh37	BTK	p.C481S	[breast cancer]	[24869598]	0.823