Gene_Symbol	UniProtKB_Accession	Amino_acid_substitution	Pathogenicity_based_on_InSiGHT_class_or_PON-MMR_training_dataset	Probability_of_pathogenicity_predicted_by_PON-MMR2
MLH1	P40692	C39Y	pathogenic	0.96
MLH1	P40692	D41H	pathogenic	0.64
MLH1	P40692	C77R	pathogenic	0.67
MLH1	P40692	T82A	pathogenic	0.71
MLH1	P40692	I107R	pathogenic	0.87
MLH1	P40692	A111V	pathogenic	0.93
MLH1	P40692	A128P	pathogenic	0.97
MLH1	P40692	G244D	pathogenic	0.96
MLH1	P40692	L260R	pathogenic	0.71
MLH1	P40692	R385C	pathogenic	0.79
MLH1	P40692	P648S	pathogenic	0.332
MLH1	P40692	G54E	pathogenic	0.56
MLH1	P40692	R226L	pathogenic	0.352
MLH1	P40692	P654L	pathogenic	0.99
MLH1	P40692	Q701H	pathogenic	0.36
MLH1	P40692	K618R	neutral	0.05
MLH1	P40692	P581L	neutral	0.36
MLH1	P40692	A281V	neutral	0.25
MLH1	P40692	I68V	neutral	0.26
MLH1	P40692	P603R	neutral	0.74
MLH1	P40692	Q701K	neutral	0.02
MLH3	Q9UHC1	N499S	neutral	0.002
MSH2	P43246	E878D	pathogenic	0.56
MSH2	P43246	G504R	pathogenic	0.52
MSH2	P43246	P652H	pathogenic	0.98
MSH2	P43246	V163D	pathogenic	0.85
MSH2	P43246	V722I	neutral	0.24
MSH2	P43246	L390F	neutral	0.63
MSH6	P52701	L449P	pathogenic	0.97
PMS2	P54278	T511M	neutral	0.03
MLH1	P40692	G101S	pathogenic	0.89
MSH2	P43246	V163G	pathogenic	0.9
MSH2	P43246	V200D	pathogenic	0.86
PMS2	P54278	I18V	neutral	0.37
MLH1	P40692	T116P	pathogenic	0.69
MSH2	P43246	A763P	pathogenic	0.97
MSH2	P43246	F694S	pathogenic	0.87
MSH2	P43246	K675E	pathogenic	0.89
MSH2	P43246	V655I	neutral	0.16
MSH2	P43246	V470G	pathogenic	0.92
MSH2	P43246	L440P	pathogenic	0.34
MSH2	P43246	L341P	pathogenic	0.99
MSH2	P43246	Y165D	pathogenic	0.79
MSH6	P52701	L1063R	pathogenic	0.97
PMS2	P54278	K541E	neutral	0