1. Variation datasets affecting protein tolerance

PredictSNP benchmark datasets

These datasets were developed and used for the evaluation of selected prediction tools and for training of the consensus classifier PredictSNP. The sets are:

• The neutral dataset. Download: Neutral variants
• The deleterious dataset. Download: Pathogenic variants

F3 contains PredictSNPbenchmark dataset with 19800 deleteriuos and 24082 neutral variations. F4 contains OVERFIT testing dataset with 17695 deleteriuos and 15081 neutral variations. F5 contains PMD testing dataset with 2249 deleterious and 1248 neutral variations. F6 contains MMP testing dataset with 4456 deleteriuos and 7538 neutral variations.

Reference:

1. Download:     F3,      F4,     F5,      F6

Bendl J, Stourac J, Salanda O, Pavelka A, Wieben E, Zendulka J, Brezovsky J and Damborsky J, 2014.
PredictSNP: Robust and accurate consensus classifier for prediction of disease-related mutations.
PLoS Comput Biol 10(1): e1003440. doi:10.1371/journal.pcbi.1003440   PUBMED