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 - databases for immunodeficiency-causing variations

   ADAbase
   Variation registry for  Adenosine deaminase deficiency (ADA)


Aminoacid substitutions - ADAbase

 - indicates amino acid change that require more complex mutation than single nucleotide substitution.
Aminoacid substitutions
Hydrophilic
HydrophobicAcidicBasicPolarSpecial
--> AFILMVWYDEHKRNQSTCGPTotal
A ----7--2-----3-12
F -------------0
I ----------0
L -21----1----59
M -----------2---2
V 4-----------4
W ---------------0
Y -----------1--1
D ------------0
E -------1------1
H ------1------1
K ------------0
R --1-6---8-92228
N ------------0
Q -------------11
S 2-------2
T -2----------2
C -------------0
G ----1-11--10--1-1-15
P --3--------4--7
Total 002669604181110131540885
Aminoacid substitutions (%)
Hydrophilic
HydrophobicAcidicBasicPolarSpecial
--> AFILMVWYDEHKRNQSTCGPTotal
A ----8.2--2.4-----3.5-14.1
F -------------0.0
I ----------0.0
L -2.41.2----1.2----5.910.6
M -----------2.4---2.4
V 4.7-----------4.7
W ---------------0.0
Y -----------1.2--1.2
D ------------0.0
E -------1.2------1.2
H ------1.2------1.2
K ------------0.0
R --1.2-7.1---9.4-10.62.42.432.9
N ------------0.0
Q -------------1.21.2
S 2.4-------2.4
T -2.4----------2.4
C -------------0.0
G ----1.2-1.21.2--11.8--1.2-1.2-17.6
P --3.5--------4.7--8.2
Total 0.00.02.47.17.110.67.10.04.71.29.41.212.90.015.31.25.94.70.09.4100.0

Codon changes - ADAbase

  a
a
a		 a
a
c		 a
a
g		 a
a
t		 a
c
a		 a
c
c		 a
c
g		 a
c
t		 a
g
a		 a
g
c		 a
g
g		 a
g
t		 a
t
a		 a
t
c		 a
t
g		 a
t
t		 c
a
a		 c
a
c		 c
a
g		 c
a
t		 c
c
a		 c
c
c		 c
c
g		 c
c
t		 c
g
a		 c
g
c		 c
g
g		 c
g
t		 c
t
a		 c
t
c		 c
t
g		 c
t
t		 g
a
a		 g
a
c		 g
a
g		 g
a
t		 g
c
a		 g
c
c		 g
c
g		 g
c
t		 g
g
a		 g
g
c		 g
g
g		 g
g
t		 g
t
a		 g
t
c		 g
t
g		 g
t
t		 t
a
a		 t
a
c		 t
a
g		 t
a
t		 t
c
a		 t
c
c		 t
c
g		 t
c
t		 t
g
a		 t
g
c		 t
g
g		 t
g
t		 t
t
a		 t
t
c		 t
t
g		 t
t
t		 Total
aaa                                                                 0
aac                                                                 0
aag                                                                 0
aat                                                                 0
aca             2                                                   2
acc                                                                 0
acg                                                                 0
act                                                                 0
aga                                                                 0
agc                                                                 0
agg                                                                 0
agt                                                                 0
ata                                                                 0
atc                                                                 0
atg       2                                                         2
att                                                                 0
caa                                                                 0
cac                                                                 0
cag                       1                           15             16
cat                                    1                            1
cca                 1                                               1
ccc                                                                 0
ccg                   3           3                                 6
cct                                                                 0
cga                 1                                       4       5
cgc                  5                                       1      6
cgg                   8   2       1                           6     17
cgt                    3                                       1    4
cta                                                                 0
ctc                                                                 0
ctg               2       5   1                   1                 9
ctt                                                                 0
gaa                                                                 0
gac                                                                 0
gag   1                                                             1
gat                                                                 0
gca                                                                 0
gcc      3                           2                              5
gcg                                               7                 7
gct                                                                 0
gga         2                                                       2
ggc          1                       1           1           1      4
ggg           8                       1                             9
ggt                                                                 0
gta                                                                 0
gtc                                                                 0
gtg               4                                                 4
gtt                                                                 0
taa                                                                 0
tac                                                                 0
tag                                                                 0
tat                                                            1    1
tca                                                                 0
tcc                                                                 0
tcg                                                               2 2
tct                                                                 0
tga                                                                 0
tgc                                                                 0
tgg                                                                 0
tgt                                                                 0
tta                                                                 0
ttc                                                                 0
ttg                                                                 0
ttt                                                                 0
Total 001003202180206025113008000100040031100000000018000150000042620020104

-->(%) a
a
a		 a
a
c		 a
a
g		 a
a
t		 a
c
a		 a
c
c		 a
c
g		 a
c
t		 a
g
a		 a
g
c		 a
g
g		 a
g
t		 a
t
a		 a
t
c		 a
t
g		 a
t
t		 c
a
a		 c
a
c		 c
a
g		 c
a
t		 c
c
a		 c
c
c		 c
c
g		 c
c
t		 c
g
a		 c
g
c		 c
g
g		 c
g
t		 c
t
a		 c
t
c		 c
t
g		 c
t
t		 g
a
a		 g
a
c		 g
a
g		 g
a
t		 g
c
a		 g
c
c		 g
c
g		 g
c
t		 g
g
a		 g
g
c		 g
g
g		 g
g
t		 g
t
a		 g
t
c		 g
t
g		 g
t
t		 t
a
a		 t
a
c		 t
a
g		 t
a
t		 t
c
a		 t
c
c		 t
c
g		 t
c
t		 t
g
a		 t
g
c		 t
g
g		 t
g
t		 t
t
a		 t
t
c		 t
t
g		 t
t
t		 Total
aaa                                                                 0
aac                                                                 0
aag                                                                 0
aat                                                                 0
aca             2                                                   2
acc                                                                 0
acg                                                                 0
act                                                                 0
aga                                                                 0
agc                                                                 0
agg                                                                 0
agt                                                                 0
ata                                                                 0
atc                                                                 0
atg       2                                                         2
att                                                                 0
caa                                                                 0
cac                                                                 0
cag                       1                           14             15
cat                                    1                            1
cca                 1                                               1
ccc                                                                 0
ccg                   3           3                                 6
cct                                                                 0
cga                 1                                       4       5
cgc                  5                                       1      6
cgg                   8   2       1                           6     16
cgt                    3                                       1    4
cta                                                                 0
ctc                                                                 0
ctg               2       5   1                   1                 9
ctt                                                                 0
gaa                                                                 0
gac                                                                 0
gag   1                                                             1
gat                                                                 0
gca                                                                 0
gcc      3                           2                              5
gcg                                               7                 7
gct                                                                 0
gga         2                                                       2
ggc          1                       1           1           1      4
ggg           8                       1                             9
ggt                                                                 0
gta                                                                 0
gtc                                                                 0
gtg               4                                                 4
gtt                                                                 0
taa                                                                 0
tac                                                                 0
tag                                                                 0
tat                                                            1    1
tca                                                                 0
tcc                                                                 0
tcg                                                               2 2
tct                                                                 0
tga                                                                 0
tgc                                                                 0
tgg                                                                 0
tgt                                                                 0
tta                                                                 0
ttc                                                                 0
ttg                                                                 0
ttt                                                                 0
Total 001003202180206025113008000100040031100000000018000140000042620020100
    indicates codon change that require more complex mutation than single nucleotide substitution.
    indicates codon change that single nucleotide doesn't change amino acid (silent mutation).

Nucleotide substitutions - ADAbase

Purines/Pyrimidines
PurinesPyrimidines
-->AGCTTotal
A 0 2 1 0 3
G 46 0 3 3 52
C 8 2 0 41 51
T 4 1 7 0 12
Total 58 5 11 44 118
Amino/Keto
AminoKeto
-->ACGTTotal
A 0 1 2 0 3
C 8 0 2 41 51
G 46 3 0 3 52
T 4 7 1 0 12
Total 58 11 5 44 118
Weak/Strong
WeakStrong
-->ATCGTotal
A 0 0 1 2 3
T 4 0 7 1 12
C 8 41 0 2 51
G 46 3 3 0 52
Total 58 44 11 5 118
Purines/Pyrimidines (%)
PurinesPyrimidines
-->AGCTTotal
A 0.0 1.7 0.8 0.0 2.5
G 39.0 0.0 2.5 2.5 44.1
C 6.8 1.7 0.0 34.7 43.2
T 3.4 0.8 5.9 0.0 10.2
Total 49.2 4.2 9.3 37.3 100.0
Amino/Keto (%)
AminoKeto
-->ACGTTotal
A 0.0 0.8 1.7 0.0 2.5
C 6.8 0.0 1.7 34.7 43.2
G 39.0 2.5 0.0 2.5 44.1
T 3.4 5.9 0.8 0.0 10.2
Total 49.2 9.3 4.2 37.3 100.0
Weak/Strong (%)
WeakStrong
-->ATCGTotal
A 0.0 0.0 0.8 1.7 2.5
T 3.4 0.0 5.9 0.8 10.2
C 6.8 34.7 0.0 1.7 43.2
G 39.0 2.5 2.5 0.0 44.1
Total 49.2 37.3 9.3 4.2 100.0
Transitions and Transversions
-->PurinePyrimidine
Purine487
Pyrimidine1548
Transitions and Transversions (%)
-->PurinePyrimidine
Purine40.75.9
Pyrimidine12.740.7