Male or female patient with abnormal NBT or chemiluminescence in activated neutrophils (less than 5% of control) who has one of the following:
Male or female patient with abnormal NBT or respiratory burst in activated neutrophils (less than 5% of control) who has one of the following:
Patients with the X-linked form of CGD (60-70% of patients) tend to present earlier and have more severe disease than patients with autosomal recessive forms. Most patients with X-CGD develop failure to thrive, severe bacterial adenitis, abscesses or osteomyelitis within the first year of life. Pneumonia and lymphadenitis due to catalase-positive organisms (particularly Staphylococcus) or fungi are the most common infections. Symptoms of intestinal or urinary tract obstruction can be caused by granuloma formation. Rarely, in both the X-linked and autosomal recessive forms, the first severe symptoms are not recognized until adulthood.