MAC inhibitor (CD59) deficiency

The CD59 is an 18- to 25-kD glycoprotein expressed on all human peripheral blood leukocytes, erythrocytes. CD59 prevent intravascular complement attack. Antigens encoded by both Ly6 and CD59 genes are important to T-cell and NK-cell function.

Alternative names

Antigen p18-20 deficiency

Protectin deficiency

Classification

  • Defects of complement regulatory proteins

Inheritance

Autosomal recessive

OMIM

+107271 CD59 antigen p18-20; CD59

Cross references

Phenotypically related immunodeficiencies

IDR factfile for Decay-accelerating factor (CD55) deficiency

Incidence

Incidence is not known.