X-linked chronic granulomatous disease

X-linked chronic granulomatous disease (X-CGD) is characterized by a defect of intracellular bacterial killing in neutrophils and monocytes, due to a failure of superoxide, oxygen radical, and peroxide production. Organisms that are catalase negative are killed normally, whereas catalase-positive organisms (Staphylococcus aureus, Aspergillus, Nocardia, and Serratia) cause major problems.

Alternative names

X-CGD

Classification

  • Defects of phagocyte function
    • Chronic granulomatous disease

Inheritance

X-linked

OMIM

#306400 Granulomatous disease, chronic; CGD

*300481 Cytochrome b(-245), beta subunit; CYBB

Incidence

1: 200,000-250,000 live births in USA. Internationally 1: 500,000.