Common variable immunodeficiency of unknown origin

Common variable immunodeficiency is a heterogeneous group of diseases of unknown etiology. Patients have low serum immunoglobulin concentrations, defective specific antibody production and an increased susceptibility to bacterial infections of the respiratory and and gastrointestinal tracts. Most CVID patients have normal numbers of circulating T cells and surface immunoglobulin-positive B cells. CVID may present at any age from childhood to old age. The peak of presentation is in early childhood and early adulthood.

Alternative names

CVID

common variable hypogammaglobulinemia

hypogammaglobulinemia

adult-onset agammaglobulinemia

late-onset hypogammaglobulinemia

acquired agammaglobulinemia

immunoglobulin deficiency, late-onset

Classification

  • Deficiencies predominantly affecting antibody production
    • Common variable immunodeficiency

Inheritance

Complex

OMIM

%240500 Common variable immunodeficiency

Cross references

Phenotypically related immunodeficiencies

IDR factfile for IgA deficiency

Incidence

1: 50,000