Interleukin 7 receptor deficiency

Gene Information

Names

HUGO name: IL7R

Alias(es):

  • CD127
  • CDW127
  • IL-7R-alpha
  • CD127 antigen
  • Interleukin 7 receptor
  • Interleukin 7 receptor alpha chain
  • Interleukin-7 receptor alpha chain precursor
  • CDw127

Localization

Reference sequences

Chromosomal location

Maps

Markers

Protein Information

Description

Protein function:

Receptor for interleukin-7

Subunit:

Heterodimer of an alpha chain and a common gamma chain

Subcellular location:

Type I membrane protein (isoforms h20 and h1); secreted (isoform h6)

Alternative products:

Event=alternative splicing; named isoforms=3; name=h20; isoid=p16871-1; sequence=displayed; name=h1; isoid=p16871-2; sequence=vsp_001714; name=h6; synonyms=secreted; isoid=p16871-3; sequence=vsp_001713;

Similarity:

Belongs to the type I cytokine family of receptors. Subfamily 4

Database:

Name=prow; note=cd guide cd127 entry;

Structures (PDB)

Domains

Extracellular domain: 21-239

    Cytoplasmic domain: 265-459

      Fibronectin type-III domain: 128-224

        Ser/Thr-rich domain: 184-189

          Other features

          Signal peptide: 1-20

            Interleukin-7 receptor alpha chain: 21-459

              N-linked (glcnac...) glycosylation sites: 49,65,151,182,232,233

                Other related resourses:

                Expression

                Expression pattern for human

                Tissue Expression (%) Clones
                pooled 16.47 8:5702
                alveolar macrophage 13.11 1:895
                leukopheresis 9.06 6:7769
                large cell carcinoma, undifferentiated 6.70 3:5253
                lymphocyte 6.35 1:1849
                prostate 5.25 1:2237
                senescent fibroblast 3.70 3:9520
                fibrosarcoma 3.16 1:3710
                lung focal fibrosis 3.00 1:3912
                lung 2.76 3:12769
                pooled 16.47 8:5702
                alveolar macrophage 13.11 1:895
                leukopheresis 9.06 6:7769
                large cell carcinoma, undifferentiated 6.70 3:5253
                lymphocyte 6.35 1:1849
                prostate 5.25 1:2237
                senescent fibroblast 3.70 3:9520
                fibrosarcoma 3.16 1:3710
                lung focal fibrosis 3.00 1:3912
                lung 2.76 3:12769