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The patients have lymphadenopathy, splenomegaly, and defective CD95-mediated apoptosis. They present recurrent sinopulmonary and herpes simplex virus infections and poor responses to immunization.
Diagnosis
Diagnostic recommendations
Additional Information
Diagnostic laboratories
Clinical:
Genetic:
Therapeutic options
Research programs, clinical trials
- European Initiative for Primary Immunodeficiencies.
- APLSbase, Jennifer Puck, National Human Genome Research Institute
- Pyrimethamine to Treat Autoimmune Lymphoproliferative Syndrome, ClinicalTrial.gov
- Study of Autoimmune Lymphoproliferative Syndrome (ALPS), ClinicalTrial.gov
- Genetic Analysis of Immune Disorders, ClinicalTrial.gov