Neutrophil-specific granule deficiency

Gene Information

Names

HUGO name: CEBPE

Alias(es):

  • C/EBP-epsilon
  • CRP1
  • CCAAT/enhancer binding protein (C/EBP), epsilon

Localization

Reference sequences

Chromosomal location

Maps

Markers

Protein Information

Description

Protein function:

C/EBP are DNA-binding proteins that recognize two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers

Subunit:

Binds DNA as a dimer and can form stable heterodimers with C/EBP delta.

Subcellular location:

Nuclear

Post-translational modification:

Phosphorylated

Tissue specificity:

Strongest expression occurs in promyelocyte and late-myeloblast-like cell lines.

Similarity:

Belongs to the bzip family. C/EBP subfamily.

Structures (PDB)

Domains

Leucine-zipper domain: 239-267

    Other features

    DNA-binding region Basic motif: 208-228

      Other related resourses:

      Expression

      Expression pattern for human

      Tissue Expression (%) Clones
      subchondral bone 77.55 2:5896
      hippocampus 12.25 1:18660
      embryonal carcinoma, cell line 9.68 1:23620
      unclassified 0.52 2:879462
      subchondral bone 77.55 2:5896
      hippocampus 12.25 1:18660
      embryonal carcinoma, cell line 9.68 1:23620
      unclassified 0.52 2:879462