ICOS deficiency

ICOS deficiency it is a form of common variable immunodeficiency caused by mutation in the ICOS gene, the "inducible costimulator". ICOS has critical involvement in T cell help for late B cell differentiation, class-switching and memory B cell generation.

Alternative names

ICOSD

Inducible costimulator deficiency

Classification

  • Deficiencies predominantly affecting antibody production
    • Common variable immunodeficiency

Inheritance

Autosomal recessive

OMIM

#607594 ICOS deficiency

%240500 Common variable immunodeficiency

*604558 Inducible costimulator; ICOS

Cross references

Phenotypically related immunodeficiencies

IDR factfile for Common variable immunodeficiency

Incidence

Incidence is not known.