IRAK4 deficiency

Gene Information

Names

HUGO name: IRAK4

Alias(es):

  • LOC51135
  • NY-REN-64
  • REN64
  • Interleukin-1 receptor associated kinase 4
  • Hypothetical protein FLJ20521
  • Interleukin-1 receptor associated kinase 4 mutant form 1
  • Interleukin-1 receptor associated kinase 4 mutant form 2

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Involved in IL1R-induced NF-kappa-B (NFkB) activation as well as the activation of mitogen-activated protein (MAP) kinase pathways. Phosphorylates IRAK1.

Subunit:

Interacts with TRAF6 and IRAK1.

Belongs to the Ser/Thr protein kinase family. Pelle subfamily.

Expression

Expression pattern for human

Tissue Expression (%) Clones
ovary 34.27 1:880
natural killer cells, cell line 11.01 2:5480
neuroepithelial cells 9.91 1:3043
leukopheresis 7.76 2:7769
embryonic stem cells 6.28 1:4803
from chronic myelogenous leukemia 4.92 1:6125
glioblastoma 4.26 1:7072
hypernephroma, cell line 3.76 1:8027
leukocyte 3.41 1:8838
endometrium, adenocarcinoma cell line 2.99 1:10072
ovary 34.27 1:880
natural killer cells, cell line 11.01 2:5480
neuroepithelial cells 9.91 1:3043
leukopheresis 7.76 2:7769
embryonic stem cells 6.28 1:4803
from chronic myelogenous leukemia 4.92 1:6125
glioblastoma 4.26 1:7072
hypernephroma, cell line 3.76 1:8027
leukocyte 3.41 1:8838
endometrium, adenocarcinoma cell line 2.99 1:10072

Animal models

Mouse