Ataxia-telangiectasia-like disorder

Gene Information

Names

HUGO name: MRE11A

Alias(es):

  • ATLD
  • HNGS1
  • MRE11
  • MRE11B
  • DNA recombination and repair protein
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)
  • Double-strand break repair protein MRE11A
  • Endo/exonuclease Mre11
  • Meiotic recombination (S. cerevisiae) 11 homolog
  • Meiotic recombination (S. cerevisiae) 11 homolog A
  • Double-strand break repair protein MRE11A

Localization

Reference sequences

Chromosomal location

Maps

Markers

Protein Information

Description

Protein function:

Involved in DNA double-strand break repair (dsbr). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic dsb processing.

Subunit:

Forms a complex with rad50.

Subcellular location:

Nuclear

Cofactor:

Manganese

Similarity:

Belongs to the mre11/rad32 family.

Expression

Expression pattern for human

Tissue Expression (%) Clones
embryonic stem cells 5.71 2:4803
bone marrow stroma 5.42 2:5056
moderately differentiated adenocarcinoma 4.93 1:2782
neuroblastoma cot 50-normalized 4.90 1:2799
neuroepithelial cells 4.50 1:3043
whole embryo, mainly head 4.05 1:3384
glioblastoma 3.88 2:7072
enchondroma cell line 3.64 1:3767
cell line 3.48 1:3934
placenta 3.32 2:8261
embryonic stem cells 5.71 2:4803
bone marrow stroma 5.42 2:5056
moderately differentiated adenocarcinoma 4.93 1:2782
neuroblastoma cot 50-normalized 4.90 1:2799
neuroepithelial cells 4.50 1:3043
whole embryo, mainly head 4.05 1:3384
glioblastoma 3.88 2:7072
enchondroma cell line 3.64 1:3767
cell line 3.48 1:3934
placenta 3.32 2:8261

Animal models

Mouse