CIITA, MHCII transactivating protein deficiency

Gene Information

Names

HUGO name: CIITA

Alias(es):

  • C2TA
  • MHC2TA
  • MHC class II transactivator
  • MHC class II transactivator CIITA

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Essential for transcriptional activity of the HLA class II promoter; activation is via the proximal promoter. No DNA binding of in vitro translated CIITA was detected. May act in a coactivator-like fashion through protein-protein interactions by contacting factors binding to the proximal MHC class II promoter, to elements of the transcription machinery, or both. Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter.

Structures (PDB)

Domains

Nacht domain: 414-724

    Asp/glu-rich (acidic) domain: 52-137

      Other features

      ATP nucleotide phosphate-binding region: 420-427

        Other related resourses:

        Expression

        Expression pattern for human

        Tissue Expression (%) Clones
        leukopheresis 26.94 3:4557
        tonsil, enriched for germinal center B-cells 22.41 20:36522
        lymph 14.62 23:64395
        blood 6.47 2:12646
        lung metatastic chondrosarcoma 6.35 1:6448
        pool, lung+testis+B-cell 5.88 8:55714
        leukocyte 4.56 1:8982
        pancreas, exocrine 3.82 2:21418
        testis 2.36 5:86533
        breast 1.94 2:42231

        Animal models

        Mouse

        Fly

        C. elegans