GFI1 deficiency

Gene Information

Names

HUGO name: GFI1

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

May be a transcription factor involved in regulating the expression of genes active in the S phase during cell cycle progression in T cells. May be involved in tumor progression. Represses ELA2 transcription.

Subcellular location:

Nuclear

Similarity:

Contains 6 c2h2-type zinc fingers.

Structures (PDB)

Domains

GLY/ALA-RICH domain: 158-209

    Other features

    Zinc finger region C2h2-type 1: 255-278

      Zinc finger region C2h2-type 2: 284-306

        Zinc finger region C2h2-type 3: 312-334

          Zinc finger region C2h2-type 4: 340-362

            Zinc finger region C2h2-type 5: 368-390

              Zinc finger region C2h2-type 6: 396-419

                Other related resourses:

                Expression

                Expression pattern for human

                Tissue Expression (%) Clones
                tHYMUS 70.72 2:2217
                pooled 13.75 1:5703
                bone_Marrow 5.34 2:29369
                lung 3.44 10:227901
                pancreas 2.32 2:67592
                testis 1.46 2:107669
                lymph_Node 1.38 2:113869
                mixed 1.00 4:314320
                uterus 0.61 1:128533
                tHYMUS 70.72 2:2217
                pooled 13.75 1:5703
                bone_Marrow 5.34 2:29369
                lung 3.44 10:227901
                pancreas 2.32 2:67592
                testis 1.46 2:107669
                lymph_Node 1.38 2:113869
                mixed 1.00 4:314320
                uterus 0.61 1:128533

                Animal models

                Mouse