CD64 deficiency

Gene Information

Names

HUGO name: FCGR1A

Alias(es):

  • CD64
  • FCRI
  • IGFR1
  • Fc fragment of IgG, high affinity Ia, receptor for
  • Fc-gamma receptor I A1
  • High affinity immunoglobulin gamma Fc receptor I precursor

Localization

Reference sequences

Chromosomal location

Maps

Markers

Protein Information

Description

Protein function:

Binds to the Fc region of Immunoglobulins gamma. High affinity receptor.

Subcellular location:

Type I membrane protein.

Tissue specificity:

Monocyte/macrophage specific.

Similarity:

Contains 3 Immunoglobulin-like C2-type domains.

Database:

Name=prow; note=cd guide cd64 entry;

Structures (PDB)

Domains

Extracellular domain: 17-292

    Cytoplasmic domain: 314-374

      Ig-like C2-type 1 domain: 22-101

        Ig-like C2-type 2 domain: 95-184

          Ig-like C2-type 3 domain: 190-277

            Other features

            Signal peptide: 1-16

              High affinity immunoglobulin gamma fc receptor i: 17-374

                Disulfide bond: 43-85

                  Disulfide bond: 124-168

                    Disulfide bond: 212-260

                      N-linked (glcnac...) glycosylation sites: 59,78,152,159,163,195,240

                        Other related resourses:

                        Expression

                        Expression pattern for human

                        Tissue Expression (%) Clones
                        vascular 86.00 1:18887
                        brain 10.17 2:319574
                        other 3.83 1:423795
                        vascular 86.00 1:18887
                        brain 10.17 2:319574
                        other 3.83 1:423795