RFX-5, MHCII promoter X box regulatory factor 5 deficiency

Gene Information

Names

HUGO name: RFX5

Alias(es):

  • regulatory factor X, 5
  • DNA-binding protein RFX5
  • Regulatory factor X subunit 5

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Activates transcription from class II MHC promoters. Recognizes X-boxes. Mediates cooperative binding between RFX and nf-y. RFX binds the X1 box of MHC-II promoters.

Subunit:

RFX consists of at least three different subunits; RFXAP, RFX5 and RFX-B/RFXANK; with each subunit representing a separate complementation group. RFX forms cooperative DNA binding complexes with x2bp and cbf/nf-y. RFX associates with CIITA to form an active transcriptional complex.

Subcellular location:

Nuclear

Post-translational modification:

Phosphorylated

Other features

DNA-binding region: 92-168

    Other related resourses:

    Expression

    Expression pattern for human

    Tissue Expression (%) Clones
    dorsal root ganglia 12.05 1:1021
    colonic mucosa with ulcerative colitus 10.10 1:1218
    foveal and macular retina 9.13 3:4045
    uterus, endometrium 6.87 1:1790
    leukopheresis 5.40 2:4557
    esophagus 4.17 1:2949
    thymus, pooled 3.88 1:3169
    bone 2.95 3:12499
    lymph 2.87 15:64395
    germ cell 2.45 4:20077

    Animal models

    Mouse

    Fly

    C. elegans