Natural killer deficiency

Gene Information

Names

HUGO name: FCGR3A

Alias(es):

  • CD16
  • FCG3
  • FCGR3
  • IGFR3
  • Fc fragment of IgG, low affinity III, receptor for CD16
  • Fc fragment of IgG, low affinity IIIa, receptor for CD16
  • Low affinity immunoglobulin gamma Fc region receptor III-A precursor
  • IgG FC receptor III-2
  • Fc-gamma RIII-alpha
  • Fc-gamma RIIIA
  • FcRIIIA
  • Fc-gamma RIII
  • FcRIII
  • CD16-A
  • FcR-10

Localization

Reference sequences

Chromosomal location

Maps

Markers

Protein Information

Description

Protein function:

Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (adcc) and other antibody-dependent responses, such as phagocytosis.

Subunit:

Exists as a hetero-oligomeric receptor complex with Fc epsilon receptor I gamma subunit and / or the CD3 zeta subunit.

Subcellular location:

Type I membrane protein (potential). Exists also as a soluble receptor.

Post-translational modification:

Glycosylated. Contains high mannose-and complex-type oligosaccharides.

Miscellaneous:

Encoded by one of two nearly indentical genes: FCGR3A and FCGR3B which are expressed in a tissue-specific manner. The PHE-203 in III-a determines the transmembrane domains whereas the SER-203 in III-b determines the GPI-anchoring.

Polymorphism:

Isoform VAL-157 shows a higher binding capacity of IgG1, IgG3 and IgG4 compared with isoform PHE-157. Alleles LEU-66 and PHE-157, and alleles HIS-66 / ARG-66 and VAL-157 are in linkage desequilibrium.

Tissue specificity:

Expressed on natural killer cells, macrophages, subpopulation of T cells, immature thymocytes and placental trophoblasts.

Similarity:

Contains 2 immunoglobulin-like C2-type domains.

Structures (PDB)

Domains

Extracellular domain: 17-208

    Cytoplasmic domain: 230-254

      Ig-like C2-type 1 domain: 24-105

        Ig-like C2-type 2 domain: 107-189

          Other features

          Signal peptide: 1-16

            Low affinity immunoglobulin gamma fc region receptor iii-a: 17-254

              Disulfide bond: 47-89

                Disulfide bond: 128-172

                  N-linked (glcnac...) glycosylation sites: 56,63,92,180,187

                    Other related resourses:

                    Expression

                    Expression pattern for human

                    Tissue Expression (%) Clones
                    colon 12.32 6:82275
                    placenta 9.48 8:142648
                    ovary 9.44 4:71634
                    peripheral_nervous_system 8.04 1:21019
                    pancreas 7.50 3:67592
                    kidney 7.41 5:113979
                    prostate 7.00 4:96523
                    other 5.98 15:423795
                    mixed 5.91 11:314320
                    brain 5.82 11:319574