p56 Lck deficiency

Gene Information

Names

HUGO name: LCK

Alias(es):

  • Lymphocyte-specific protein tyrosine kinase
  • Proto-oncogene tyrosine-protein kinase
  • P56-LCK
  • LSK
  • T cell-specific protein-tyrosine kinase

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

May participate in antigen-induced T-cell activation.

Catalytic activity:

ATP + a protein tyrosine = ADP + a protein tyrosine phosphate.

Subunit:

Binds to phosphatidylinositol 3'-kinase (PI3k) from T lymphocytes through its SH3 domain and to the tyrosine phosphorylated form of khdrbs1/p70 through its SH2 domain. Binds to HIF-1 nef through its SH3 domain. This interaction inhibits its tyrosine-kinase activity.

Subcellular location:

Bound to the cytoplasmic domain of either CD4 or CD8.

Similarity:

Belongs to the tyr protein kinase family. Src subfamily.

Structures (PDB)

1BHF P56Lck Sh2 Domain Inhibitor Complex
1BHH Free P56Lck Sh2 Domain
1CWD Human P56Lck Tyrosine Kinase Complexed With Phosphonopeptide
1CWE Human P56Lck Tyrosine Kinase Complexed With Phosphonopeptide
1FBZ Structure-Based Design Of A Novel, Osteoclast-Selective, Nonpeptide Src Sh2 Inhibitor With In Vivo Anti-Resorptive Activity
1H92 Sh3 Domain Of Human Lck Tyrosine Kinase
1IJR Crystal Structure Of Lck Sh2 Complexed With Nonpeptide Phosphotyrosine Mimetic
1KIK Sh3 Domain Of Lymphocyte Specific Kinase (Lck)
1LCJ Sh2 (Src Homology-2) Domain Of Human P56-Lck Tyrosine Kinase Complexed With The 11 Residue Phosphotyrosyl Peptide Epqpyeeipiyl
1LCK Sh3-Sh2 Domain Fragment Of Human P56-Lck Tyrosine Kinase Complexed With The 10 Residue Synthetic Phosphotyrosyl Peptide Tegqpyqpqpa
1LKK Human P56-Lck Tyrosine Kinase Sh2 Domain In Complex With The Phosphotyrosyl Peptide Ac-Ptyr-Glu-Glu-Ile (Pyeei Peptide)
1LKL Human P56-Lck Tyrosine Kinase Sh2 Domain In Complex With The Phosphotyrosyl Peptide Ac-Ptyr-Glu-Glu-Gly (Pyeeg Peptide)
1Q68 Solution Structure Of T-Cell Surface Glycoprotein Cd4 and Proto-Oncogene Tyrosine-Protein Kinase Lck Fragments
1Q69 Solution Structure Of T-Cell Surface Glycoprotein Cd8 Chain and Proto-Oncogene Tyrosine-Protein Kinase Lck Fragments
1QPC Structural Analysis Of The Lymphocyte-Specific Kinase Lck In Complex With Non-Selective and Src Family Selective Kinase Inhibitors
1QPD Structural Analysis Of The Lymphocyte-Specific Kinase Lck In Complex With Non-Selective and Src Family Selective Kinase Inhibitors
1QPE Structural Analysis Of The Lymphocyte-Specific Kinase Lck In Complex With Non-Selective and Src Family Selective Kinase Inhibitors
1QPJ Crystal Structure Of The Lymphocyte-Specific Kinase Lck In Complex With Staurosporine.
3LCK The Kinase Domain Of Human Lymphocyte Kinase (Lck), Activated Form (Auto-Phosphorylated On Tyr394)

Expression

Expression pattern for human

Tissue Expression (%) Clones
thymus 25.04 3:5542
thymus 20.57 1:2249
human embryonic stem cells 19.24 3:7214
lymph_node 12.71 32:116453
spleen 5.96 2:15523
pancreatic islet 3.35 1:13811
blood 2.90 3:47876
vascular 2.37 1:19518
pluripotent cell line derived from blastocyst inner cell mass 2.01 1:23025
other 1.36 13:442392