Printable factfile
Gene Information
Names
HUGO name: MVK
Alias(es):
- LRBP
- MVLK
- Mevalonate kinase
Localization
Reference sequences
- DNA: AF217535 (EMBL)
- cDNA: M88468 (EMBL)
- Protein: Q03426 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
May be a regulatory site in cholesterol biosynthetic pathway.
Catalytic activity:
ATP + (r)-mevalonate = ADP + (r)-5-phosphomevalonate
Subunit:
Homodimer
Subcellular location:
Cytoplasmic and peroxisomal.
Enzyme regulation:
Farnesyl- and geranyl-pyrophosphates are competitive inhibitors.
Similarity:
Belongs to the ghmp kinase family. Mevalonate kinase subfamily.
Other features
ATP nucleotide phosphate-binding region: 138-148
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| larynx | 31.85 | 1:838 |
| adrenal gland | 9.97 | 1:2677 |
| spleen | 6.88 | 4:15523 |
| small intestine | 4.86 | 1:5498 |
| embryonic stem | 4.10 | 1:6512 |
| cervix | 4.02 | 5:33205 |
| human embryonic stem cells | 3.70 | 1:7214 |
| prostate | 2.90 | 11:101396 |
| other | 2.47 | 41:442392 |
| soft_tissue | 2.32 | 1:11501 |