TMEM142 deficiency

Gene Information

Names

HUGO name: ORAI1

Alias(es):

  • TMEM142, CRACM1, FLJ14466

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Ca(2+) release-activated Ca(2+) (crac) channel subunit which mediates Ca(2+) influx following depletion of intracellular Ca(2+) stores and channel activation by the Ca(2+) sensor, stim1. Crac channels are the main pathway for Ca(2+) influx in T-cells and promote the immune response to pathogens by activating the transcription factor NFAT.

Subcellular location:

Cell membrane; multi-pass membrane protein

Miscellaneous:

In greek mythology, the 'orai' are the keepers of the gates of heaven: eunomia (order or harmony), dike (justice) and eirene (peace)

Similarity:

Belongs to the Orai family

Other features

Calcium release-activated calcium channel protein 1: 1-301

    N-linked (glcnac...) glycosylation site: 223

      Other related resourses:

      Expression

      Expression pattern for human

      Tissue Expression (%) Clones