Printable factfile
Gene Information
Names
HUGO name: SMARCAL1
Localization
Reference sequences
- DNA: IDRefSeq: D0079 (IDRefSeq)
- cDNA: AF082179 (EMBL)
- Protein: Q9NZC9 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Protein Information
Description
Protein function:
Possesses intrinsic ATP-dependent nucleosome remodelling activity (by similarity)
Subcellular location:
Nucleus (by similarity)
Tissue specificity:
Ubiquitously expressed, with high levels in testis
Similarity:
Belongs to the SNF2/RAD54 helicase family
Structures (PDB)
Domains
HARP 1 domain: 248-302
HARP 2 domain: 343-397
Helicase ATP-binding domain: 445-600
Helicase C-terminal domain: 716-869
Other features
Swi/snf-related matrix-associated actin-dependent regulator of chromatin subfamily a-like protein 1: 1-954
ATP nucleotide phosphate-binding region: 458-465
Other related resourses:
- PIR: T34557
- InterPro: IPR014001; DEAD-like_N
- InterPro: IPR010003; HARP
- InterPro: IPR014021; Helic_SF1/SF2_ATP_bd
- InterPro: IPR001650; Helicase_C
- InterPro: IPR000330; SNF2_N
- Pfam: PF07443; HARP
- Pfam: PF00271; Helicase_C
- Pfam: PF00176; SNF2_N
- SMART: SM00487; DEXDc
- SMART: SM00490; HELICc
- PROSITE: PS51192; HELICASE_ATP_BIND_1
- PROSITE: PS51194; HELICASE_CTER
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| tongue | 8.25 | 5:37267 |
| bone_marrow | 7.43 | 5:41353 |
| umbilical_cord | 6.59 | 1:9321 |
| testis | 6.30 | 29:282747 |
| thymus | 5.36 | 6:68776 |
| cervix | 4.65 | 3:39652 |
| connective_tissue | 4.48 | 7:96057 |
| blood | 4.00 | 4:61437 |
| other | 2.83 | 9:195669 |
| lymph | 2.81 | 2:43667 |