CD3Zeta deficiency

Erythroderma, protracted diarrhea, and pulmonary abscesses caused by Pseudomonas aeruginosa, recurrent episodes of herpes simplex virus infection of the mouth and skin, two episodes of oral and skin infections with Candida albicans, and two pulmonary infections, one of which was caused by Streptococcus pneumoniae.

Therapeutic options

  • Bone marrow transplantation is the only treatment of SCID. Other recommendations include intravenous gamma-globulin infusion, irradiation of all blood products, antibiotherapy.

Research programs, clinical trials