CD19 deficiency

Gene Information

Names

HUGO name: CD19

Alias(es):

  • μ
  • Immunoglobin heavy constant μ
  • immunoglobulin μ
  • Ig μ chain C region

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

May be involved in growth regulation of B-cells.

Subunit:

Interacts with Vav. Interacts with Grb2 and Sos when phosphorylated on Tyr-348 and/or Tyr-378. Interacts with Plcg2 when phosphorylated on Tyr-409.

Subcellular location:

Membrane; single-pass type I membrane protein.

Caution:

Ref.1 sequence differs from that shown due to a frameshift in position 396.

Similarity:

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Structures (PDB)

Domains

Ig-like C2-type 1 domain: 20-113

    Ig-like C2-type 2 domain: 176-277

      Other features

      Signal peptide: 1-19

        B-lymphocyte antigen cd19: 20-556

          Disulfide bond: 38-97

            Disulfide bond: 200-261

              N-linked (glcnac...) glycosylation sites: 86,125,138,181,265

                Other related resourses:

                Expression

                Expression pattern for human

                Tissue Expression (%) Clones
                spleen 33.40 33:47318
                tonsil 31.90 12:18016
                rectum 8.32 1:5759
                lymph_node 8.07 14:83039
                lymph 7.68 7:43667
                thymus 2.79 4:68776
                uncharacterized_tissue 1.78 8:215582
                connective_tissue 1.50 3:96057
                bone_marrow 1.16 1:41353
                testis 0.85 5:282747

                Animal models

                Mouse