TNFRSF13B deficiency

Gene Information

Names

HUGO name: TNFRSF13B

Alias(es):

  • TACI
  • CD267
  • CVID
  • FLJ39942

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Receptor for TNFSF13/APRIL and TNFSF13b/TAll1/BAFF/BLYS that binds both ligands with similar high affinity. Mediates calcineurin-dependent activation of NF-AT, as well as activation of NF-kappa-b and AP-1. Involved in the stimulation of B- and T-cell function and the regulation of humoral immunity.

Subunit:

Binds Traf2, Traf5 and Traf6. Binds the Nh2-terminal domain of Camlg with its C-terminus.

Subcellular location:

Membrane; single-pass type iii membrane protein

Alternative products:

Event=alternative splicing; named isoforms=2; name=1; isoid=o14836-1; sequence=displayed; name=2; isoid=o14836-2; sequence=vsp_013798;

Tissue specificity:

Highly expressed in spleen, thymus, small intestine and peripheral blood leukocytes. Expressed in resting B-cells and activated T-cells, but not in resting T-cells.

Similarity:

Contains 2 Tnfr-cys repeats.

Structures (PDB)

1XU1 .
1XUT .

Domains

Other features

Tumor necrosis factor receptor superfamily member 13b: 1-293

    Disulfide bond: 34-47

      Disulfide bond: 50-62

        Disulfide bond: 54-66

          Disulfide bond: 71-86

            Disulfide bond: 89-100

              Disulfide bond: 93-104

                N-linked (glcnac...) glycosylation site: 128

                  Other related resourses:

                  Expression

                  Expression pattern for human

                  Tissue Expression (%) Clones
                  lymph 31.36 3:43667
                  spleen 28.94 3:47318
                  small_intestine 21.31 2:42840
                  trachea 9.84 1:46384
                  unclassified 4.85 1:94133
                  uncharacterized_tissue 2.12 1:215582
                  mixed 1.58 1:288723

                  Animal models

                  Mouse