ImmunoDeficiency Resource (IDR)

Names

HUGO name: SP110

Alias(es):

Localization

Reference sequences

Chromosomal location

Maps

Variations / Mutations

• SP110base; Mutation registry for Hepatic veno-oclussive disease with immunodeficiency syndrome (VODI)

Other gene-based resources

Description

Protein function:

Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements (rare).

Subunit:

Isoform 3 interacts with HCV core protein.

Subcellular location:

Nucleus. Found in the nuclear body.

Post-translational modification:

Phosphorylated (isoform 2).

Alternative products:

Event=alternative splicing; named isoforms=5; name=1; isoid=q9hb58-1; sequence=displayed; name=2; synonyms=ifi75, 75; isoid=q9hb58-2; sequence=vsp_005992, vsp_006001, vsp_006002; name=3; synonyms=sp110b; isoid=q9hb58-3; sequence=vsp_005998, vsp_005999; name=4; synonyms=ifi41, 41; isoid=q9hb58-4; sequence=vsp_005991, vsp_005994, vsp_005995, vsp_005997, vsp_006000; name=5; isoid=q9hb58-5; sequence=vsp_005993, vsp_005996, vsp_005997, vsp_006000;

Induction:

By interferon gamma and by all-trans retinoic acid.

Tissue specificity:

Highly expressed in peripheral blood leukocytes and spleen. Detected at intermediate levels in thymus, prostate, testis, ovary, small intestine and colon, and at low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.

Similarity:

Contains 1 bromo domain.

Structures (PDB)

Domains

HSR domain: 6-109

SAND domain: 454-535

Bromo domain: 581-676

Other features

Sp110 nuclear body protein: 1-689

Zinc finger region Phd-type: 534-580

Other related resourses:

Expression pattern for human