Printable factfile
Gene Information
Names
HUGO name: F12
Localization
Reference sequences
- DNA: D0119 (IDRefSeq)
- cDNA: M31315 (EMBL)
- Protein: P00748 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Factor XII is a serum glycoprotein that participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. Prekallikrein is cleaved by Factor XII to form kallikrein, which then cleaves Factor XII first to alpha-factor XIIa and then to beta-factor XIIa. Alpha-factor XIIa activates factor XI to factor XIa
Catalytic activity:
Selective cleavage of Arg-|-ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa
Subcellular location:
Secreted
Post-translational modification:
O- and n-glycosylated. The o-linked polysaccharides were not identified, but are probably the mucin type linked to galnac
Similarity:
Belongs to the peptidase S1 family
Structures (PDB)
Domains
Fibronectin type-II domain: 42-90
EGF-like 1 domain: 94-131
Fibronectin type-I domain: 133-173
EGF-like 2 domain: 174-210
Kringle domain: 217-295
Peptidase S1 domain: 373-614
Other features
Signal peptide: 1-19
Coagulation factor XIIa heavy chain: 20-372
Beta-factor XIIa part 1: 354-362
Beta-factor XIIa part 2: 373-615
Coagulation factor XIIa light chain: 373-615
Disulfide bond: 47-73
Disulfide bond: 61-88
Disulfide bond: 98-110
Disulfide bond: 104-119
Disulfide bond: 121-130
Disulfide bond: 135-163
Disulfide bond: 161-170
Disulfide bond: 178-189
Disulfide bond: 183-198
Disulfide bond: 200-209
Disulfide bond: 217-295
Disulfide bond: 238-277
Disulfide bond: 266-290
Disulfide bond: 359-486
Disulfide bond: 397-413
Disulfide bond: 405-475
Disulfide bond: 436-439
Disulfide bond: 500-569
Disulfide bond: 532-548
Disulfide bond: 559-590
O-linked (fuc) and N-linked (glcnac...) and O-linked (galnac...) glycosylation sitess: 109,249,299,305,308,328,329,337,433
Other related resourses:
- PIR: KFHU12
- InterPro: IPR006210; EGF
- InterPro: IPR000742; EGF_3
- InterPro: IPR006209; EGF_like
- InterPro: IPR013032; EGF_like_reg
- InterPro: IPR014394; Factor_XII_HGFA
- InterPro: IPR000083; Fibrnctn1
- InterPro: IPR000562; FN_type2_col_bd
- InterPro: IPR000001; Kringle
- InterPro: IPR001254; Peptidase_S1_S6
- InterPro: IPR001314; Peptidase_S1A
- Pfam: PF00008; EGF
- Pfam: PF00039; fn1
- Pfam: PF00040; fn2
- Pfam: PF00051; Kringle
- Pfam: PF00089; Trypsin
- PRINTS: PR00722; CHYMOTRYPSIN
- PRINTS: PR00013; FNTYPEII
- PRINTS: PR00018; KRINGLE
- ProDom: PD000995; FN_Type_II
- ProDom: PD000395; Kringle
- SMART: SM00181; EGF
- SMART: SM00058; FN1
- SMART: SM00059; FN2
- SMART: SM00130; KR
- SMART: SM00020; Tryp_SPc
- PROSITE: PS00022; EGF_1
- PROSITE: PS01186; EGF_2
- PROSITE: PS50026; EGF_3
- PROSITE: PS01253; FN1_1
- PROSITE: PS51091; FN1_2
- PROSITE: PS00023; FN2_1
- PROSITE: PS51092; FN2_2
- PROSITE: PS00021; KRINGLE_1
- PROSITE: PS50070; KRINGLE_2
- PROSITE: PS50240; TRYPSIN_DOM
- PROSITE: PS00134; TRYPSIN_HIS
- PROSITE: PS00135; TRYPSIN_SER
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| ascites | 38.94 | 9:47004 |
| stomach | 16.59 | 6:73538 |
| whole_body | 7.49 | 1:27167 |
| liver | 6.42 | 5:158276 |
| mixed | 4.95 | 7:287479 |
| uncharacterized_tissue | 4.74 | 5:214464 |
| colon | 4.06 | 2:100063 |
| lung | 3.55 | 5:286589 |
| prostate | 3.45 | 2:117863 |
| uterus | 3.19 | 3:191472 |