ALPS type III

Gene Information

Names

HUGO name: NRAS

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Ras proteins bind gdp/gtp and possess intrinsic gtpase activity

Subcellular location:

Cell membrane; lipid-anchor; cytoplasmic side. Golgi apparatus membrane; lipid-anchor. Note=shuttles between the plasma membrane and the golgi apparatus

Post-translational modification:

Palmitoylated by the zdhhc9-golga7 complex. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and golgi

Enzyme regulation:

Alternate between an inactive form bound to gdp and an active form bound to gtp. Activated by a guanine nucleotide-exchange factor (gef) and inactivated by a gtpase-activating protein (gap)

Similarity:

Belongs to the small gtpase superfamily. Ras family

Other features

Gtpase nras: 1-186

    Propeptide Removed in mature form: 187-189

      GTP nucleotide phosphate-binding region: 10-17

        GTP nucleotide phosphate-binding region: 57-61

          GTP nucleotide phosphate-binding region: 116-119

            Other related resourses:

            Expression

            Expression pattern for human

            Tissue Expression (%) Clones
            vascular 8.46 7:47857
            lymph_node 7.94 11:80139
            uncharacterized_tissue 5.13 19:214464
            embryonic_tissue 5.10 4:45419
            bladder 4.57 2:25314
            bone_marrow 4.29 3:40470
            blood 3.63 5:79803
            muscle 3.43 6:101253
            skin 3.32 10:174239
            heart 3.32 4:69792

            Animal models

            Mouse