X-linked hyper-IgM syndrome (CD40L deficiency)

Gene Information

Names

HUGO name: TNFSF5

Alias(es):

  • CD154
  • CD40L
  • CD40LG
  • HIGM1
  • IGM
  • IMD3
  • TRAP
  • gp39
  • hCD40L
  • CD40 antigen ligand
  • tumor necrosis factor superfamily, member 5
  • CD40 ligand
  • TNF-related activation protein
  • TRAP
  • T cell antigen GP39

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Structures (PDB)

1ALY Crystal Structure Of Human Cd40 Ligand
1CDA Cd40 Ligand Complex With The Membrane-Bound Glycoprotein Cd40 (Theoretical Model)

Domains

Intracytoplasmic domain (IC): 1-22

    Transmembrane domain (TM): 26-46

      Tumor necrosis factor homology domain (TNFH): 123-261

        Extracellular unique domain (ECU): 47-261

          Expression

          Expression pattern for human

          Tissue Expression (%) Clones

          Animal models

          Mus musculus (Mouse)

          Rattus norvegicus (Rat)

            Bos taurus (Bovine)

              Canis familiaris (Dog)

                Felis silvestris catus (Cat)

                  Gallus gallus (Chicken)

                    Aotus trivirgatus (Night monkey) (Douroucouli)

                      Callithrix jacchus (Common marmoset)

                        Macaca mulatta (Rhesus macaque), and Cercocebus torquatus atys (Red-crowned mangabey) (Sooty mangabey)

                          Macaca nemestrina (Pig-tailed macaque)

                            Sus scrofa (Pig)