Printable factfile
Gene Information
Names
HUGO name: TYK2
Localization
Reference sequences
- DNA: D0118 (IDRefSeq)
- cDNA: X54637 (EMBL)
- Protein: P29597 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Probably involved in intracellular signal transduction by being involved in the initiation of type I IFN signaling. Phosphorylates the interferon-alpha/beta receptor alpha chain
Catalytic activity:
ATP + a [protein]-l-tyrosine = ADP + a [protein]-l-tyrosine phosphate
Tissue specificity:
Observed in all cell lines analyzed. Expressed in a variety of lymphoid and non-lymphoid cell lines
Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. Jak subfamily
Structures (PDB)
Domains
FERM domain: 26-431
SH2; atypical domain: 450-529
Protein kinase 1 domain: 589-875
Protein kinase 2 domain: 897-1176
Other features
Non-receptor tyrosine-protein kinase tyk2: 1-1187
ATP nucleotide phosphate-binding region: 903-911
Atp binding site: 930
Other related resourses:
- PIR: TVHUY2
- InterPro: IPR000299; Band_4.1_N
- InterPro: IPR009127; JAK
- InterPro: IPR009131; Non_rcpt_TYK2
- InterPro: IPR000719; Prot_kinase
- InterPro: IPR000980; SH2
- InterPro: IPR001245; Tyr_pkinase
- InterPro: IPR008266; Tyr_pkinase_AS
- Pfam: PF07714; Pkinase_Tyr
- PRINTS: PR01823; JANUSKINASE
- PRINTS: PR00109; TYRKINASE
- PRINTS: PR01827; YKINASETYK2
- ProDom: PD000001; Prot_kinase
- SMART: SM00295; B41
- SMART: SM00252; SH2
- SMART: SM00219; TyrKc
- PROSITE: PS00660; FERM_1
- PROSITE: PS00661; FERM_2
- PROSITE: PS50057; FERM_3
- PROSITE: PS00107; PROTEIN_KINASE_ATP
- PROSITE: PS50011; PROTEIN_KINASE_DOM
- PROSITE: PS00109; PROTEIN_KINASE_TYR
- PROSITE: PS50001; SH2
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| 9591 | ||
| 9591 |