Printable factfile
Gene Information
Names
HUGO name: TLR3
Localization
Reference sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Participates in the innate immune response to microbial agents. May be involved in the recognition of ds-rna. Acts via myd88 and traf6, leading to nf-kappa-b activation, cytokine secretion and the inflammatory response (by similarity)
Subunit:
Binds myd88 via their respective tir domains (by similarity)
Subcellular location:
Membrane; single-pass type i membrane protein (by similarity)
Tissue specificity:
Expressed at high level in placenta and pancreas. Also detected in cd11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors
Similarity:
Belongs to the toll-like receptor family
Domains
TIR domain: 754-896
Other features
Signal peptide: 1-23
Toll-like receptor 3: 24-904
N-linked (glcnac...) glycosylation sites: 52,57,70,124,196,247,252,265,275,291,398,413,507,636,662
Other related resourses:
- InterPro: IPR001611; LRR
- InterPro: IPR000483; LRR_C
- InterPro: IPR000372; LRR_cys_N
- InterPro: IPR003591; LRR_typ
- InterPro: IPR000157; TIR
- Pfam: PF00560; LRR_1
- Pfam: PF01463; LRRCT
- Pfam: PF01582; TIR
- PRINTS: PR00019; LEURICHRPT
- SMART: SM00369; LRR_TYP
- SMART: SM00082; LRRCT
- SMART: SM00013; LRRNT
- SMART: SM00255; TIR
- PROSITE: PS50104; TIR
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| trachea | 31.34 | 10:51029 |
| placenta | 19.51 | 23:188546 |
| spleen | 6.54 | 2:48893 |
| bladder | 6.44 | 1:24827 |
| adrenal_gland | 5.15 | 1:31044 |
| kidney | 3.32 | 4:192682 |
| colon | 3.24 | 2:98776 |
| connective_tissue | 3.23 | 2:99154 |
| muscle | 3.19 | 2:100230 |
| unclassified | 2.66 | 1:60167 |