ImmunoDeficiency Resource (IDR)

Names

HUGO name: STAT3

Localization

Reference sequences

Chromosomal location

Maps

Variations / Mutations

• STAT3base; Mutation registry for STAT3 deficiency

Other gene-based resources

Description

Protein function:

Transcription factor that binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by il31 through il31ra

Subunit:

Forms a homodimer or a heterodimer with a related family member (at least STAT1). Interacts with NCOAL, PELP1, SOCS7 and STATIP1. Interacts with HCV core protein. Interacts with IL23r in presence of IL23. Interacts with IL31ra

Subcellular location:

Cytoplasm. Nucleus. Note=translocated into the nucleus in response to phosphorylation

Post-translational modification:

Tyrosine phosphorylated in response to IL-6, IL-11, CNTF, LIF, CSF-1, EGF, PDGF, IFN-alpha and OSM. Phosphorylated on serine upon DNA damage, probably by ATM or ATR. Serine phosphorylation is important for the formation of stable DNA-binding STAT3 homodimers and maximal transcriptional activity

Alternative products:

Event=alternative splicing; named isoforms=2; name=1; isoid=p40763-1; sequence=displayed; name=del-701; isoid=p40763-2; sequence=vsp_010474;

Miscellaneous:

Involved in the GP130-mediated signaling pathway

Tissue specificity:

Heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas

Similarity:

Belongs to the transcription factor STAT family

Structures (PDB)

Domains

SH2 domain: 580-670

Other features

Signal transducer and activator of transcription 3: 1-770

Other related resourses:

Expression pattern for human

Animal models

Mouse