Printable factfile
Gene Information
Names
HUGO name: CD40
Alias(es):
- Bp50
- TNFRSF5
- p50
- CD40 antigen
- tumor necrosis factor receptor superfamily, member 5
- Tumor necrosis factor receptor superfamily member 5 precursor
- CD40L receptor
- B-cell surface antigen CD40
- CDw40
Localization
Reference sequences
- DNA: AL035662 (EMBL)
- cDNA: X60592 (EMBL)
- Protein: P25942 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Receptor for TNFSF5/CD40l.
Subcellular location:
Type I membrane protein (isoform I); secreted (isoform II).
Alternative products:
At least 2 isoforms; I) and II; are produced by alternative splicing.
Structures (PDB)
| 1CDF | TNFRSF5 |
Domains
Extracellular domain: 20-193
Cytoplasmic domain: 216-277
Other features
Signal peptide: 1-19
Tumor necrosis factor receptor superfamily member 5: 20-277
Disulfide bond: 26-37
Disulfide bond: 38-51
Disulfide bond: 41-59
Disulfide bond: 62-77
Disulfide bond: 83-103
Disulfide bond: 105-119
Disulfide bond: 111-116
Disulfide bond: 125-143
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| human eye anterior segment | 15.74 | 1:1978 |
| tonsil, enriched for germinal center B-cells | 7.67 | 9:36522 |
| B-cells | 7.53 | 4:16533 |
| leukocyte | 6.93 | 2:8982 |
| mixed | 5.16 | 10:60341 |
| lung metatastic chondrosarcoma | 4.83 | 1:6448 |
| foreskin, melanocyte | 4.62 | 2:13478 |
| lymph | 4.35 | 9:64395 |
| kidney, pooled | 4.21 | 1:7404 |
| B cells germinal | 4.13 | 1:7537 |