CD3ε deficiency

Gene Information

Names

HUGO name: CD3E

Alias(es):

  • T3E
  • TCRE
  • CD3E antigen, epsilon polypeptide (TiT3 complex)
  • T-cell surface glycoprotein CD3 epsilon chain precursor
  • T-cell surface antigen T3/LEU-4 epsilon chain

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

The CD3 complex mediates signal transduction.

Subunit:

The TCR/CD3 complex of T lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Subcellular location:

Type I membrane protein.

Structures (PDB)

Domains

Extracellular domain: 23-126

    Cytoplasmic domain: 153-207

      Other features

      Signal peptide: 1-22

        T-cell surface glycoprotein CD3 epsilon chain: 23-207

          Other related resourses:

          Expression

          Expression pattern for human

          Tissue Expression (%) Clones
          T cells from T cell leukemia 23.42 3:2397
          blood, white cells 20.56 1:910
          lymph, T-cell 13.20 6:8503
          leukocyte 12.50 6:8982
          thymus, pooled 11.81 2:3169
          spleen 5.18 2:7229
          blood 2.96 2:12646
          germ cell 2.80 3:20077
          mixed 2.17 7:60341
          rpe and choroid 1.77 1:10565

          Animal models

          Mouse

          Fly

          C. elegans