CD3γ deficiency

Gene Information

Names

HUGO name: CD3G

Alias(es):

  • T3G
  • CD3G antigen, gamma polypeptide (TiT3 complex)
  • T-cell surface glycoprotein CD3 gamma chain precursor
  • T-cell receptor T3 gamma chain

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

The CD3 complex mediates signal transduction.

Subunit:

The TCR/CD3 complex of T lymphocytes consists of either a TCR alpha/beta or TCR gamma/delta heterodimer coexpressed at the cell surface with the invariant subunits of CD3 labeled gamma, delta, epsilon, zeta, and eta.

Subcellular location:

Type I membrane protein.

Structures (PDB)

Domains

Extracellular domain: 23-111

    Cytoplasmic domain: 139-182

      Other features

      Signal peptide: 1-22

        T-cell surface glycoprotein CD3 gamma chain: 23-182

          Other related resourses:

          Expression

          Expression pattern for human

          Tissue Expression (%) Clones
          blood, white cells 56.95 1:910
          mammary gland 35.97 1:1441
          pool, liver+spleen 4.23 5:61327
          pool, lung+testis+B-cell 1.86 2:55714
          lymph 0.80 1:64395
          brain 0.19 1:274929

          Animal models

          Mouse

          Fly

          C. elegans