Printable factfile
Gene Information
Names
HUGO name: IGHG3
Alias(es):
- Immunoglobin heavy constant gamma 3
- Immunoglobulin gamma 3
- Ig gamma-3 chain C region
- Heavy chain disease protein
- HDC
Localization
Reference sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Subunit:
Dimer linked by 12 disulfide bonds; it has an extra interchain disulfide bond at position 7 in addition to the 11 normally present in the hinge region.
Structures (PDB)
Domains
Hinge domain: 12-73
Ch2 domain: 74-183
Ch3 domain: 184-289
Other features
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| breast, normal duct | 33.09 | 76:346 |
| ovary, surface epithelium | 15.86 | 4:38 |
| prostate, stroma | 9.02 | 17:284 |
| lymph node | 8.44 | 7:125 |
| spleen | 5.73 | 275:7229 |
| adipose | 3.37 | 19:849 |
| thymus | 3.35 | 10:449 |
| B-cells | 2.36 | 259:16533 |
| nasopharynx | 2.10 | 9:646 |
| genitourinary tract | 1.94 | 49:3813 |