Printable factfile
IgG sublass deficiency is clinically significant only if an impaired response to bacteria such as tetanus, diphteria, and pneumococcus occurs. IgG4 subclass deficiency is very common, affecting 10-15% of the general population. It may be isolated or associated with other IgG subclass deficiencies. The clinical significance of this disorder is still unknown.
Diagnosis
Additional Information
Therapeutic options
- Only symptomatics patients should be treated. Antibiotic therapy in case there are recurrent infections followed by intravenous immunoglobulin if infections are not controlled.
- Hypogammaglobulinemia, eMedicine
- IgA and IgG subclass deficiencies, eMedicine