Printable factfile
Gene Information
Names
HUGO name: CYBA
Alias(es):
- cytochrome b-245, alpha polypeptide
- Cytochrome b-245 light chain
- p22 phagocyte B-cytochrome
- Neutrophil cytochrome B, 22 kDa polypeptide
- p22-phox
- p22phox
- Cytochrome B(558) alpha chain
- Cytochrome b558 alpha-subunit
- Superoxide- generating NADPH oxidase light chain subunit
Localization
Reference sequences
- DNA: M61106 (GenBank)
- cDNA: M21186 (EMBL)
- Protein: P13498 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Critical component of the membrane-bound oxidase of phagocytes that generates superoxide.
Subunit:
Composed of a heavy chain (β) and a light chain (α).
Miscellaneous:
The heme prosthetic group could be coordinated with residues of the light chain, the heavy chain, or both, and it is possible that more than one heme is present per cytochrome B-245.
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| brain, miningioma | 17.86 | 1:709 |
| blood, lymphocyte | 11.18 | 10:11328 |
| B-cells | 6.89 | 9:16533 |
| mixed | 5.67 | 27:60341 |
| leukocyte | 5.64 | 4:8982 |
| osteoarthritic cartilage | 4.22 | 1:2999 |
| tonsil, enriched for germinal center B-cells | 4.16 | 12:36522 |
| aorta | 3.70 | 3:10275 |
| colon | 3.54 | 24:85835 |
| human retina | 3.14 | 1:4036 |