Gene Information
Names
HUGO name: NCF1
Alias(es):
- p47phox
- neutrophil cytosolic factor 1
- Neutrophil cytosol factor 1 (NCF-1)
- Neutrophil NADPH oxidase factor 1
- 47 kDa neutrophil oxidase factor
- p47-phox
- NCF-47K
- 47 kDa autosomal chronic granulomatous disease protein
Localization
Reference sequences
- DNA: U57833 (EMBL)
- cDNA: M25665 (EMBL)
- Protein: P14598 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
NCF2, NCF1, and a membrane bound cytochrome B558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Subcellular location:
Cytoplasmic
Structures (PDB)
1GD5 | Solution Structure Of The Px Domain From Human P47Phox Nadph Oxidase |
Domains
Px domain: 4-125
Asp/glu-rich (highly acidic) domain: 211-254
Arg/lys-rich (highly basic) domain: 292-390
SH3 1 domain: 156-215
SH3 2 domain: 226-285
Expression
Expression pattern for human
Tissue | Expression (%) | Clones |
---|---|---|
B cells from Burkitt lymphoma | 25.57 | 7:2143 |
blood, lymphocyte | 12.44 | 18:11328 |
leukocyte | 8.71 | 10:8982 |
blood, white cells | 8.60 | 1:910 |
tonsil, enriched for germinal center B-cells | 8.36 | 39:36522 |
colonic mucosa with ulcerative colitus | 6.43 | 1:1218 |
B-cells | 6.15 | 13:16533 |
lymph | 5.71 | 47:64395 |
leukopheresis | 3.44 | 2:4557 |
osteoarthritic cartilage | 2.61 | 1:2999 |