Printable factfile
Gene Information
Names
HUGO name: NCF2
Alias(es):
- p67phox
- neutrophil cytosolic factor 2
- Neutrophil NADPH oxidase factor 2
- 67 kDa neutrophil oxidase factor
Localization
Reference sequences
- DNA: NCF2_DNA (IDRefSeq)
- cDNA: M32011 (EMBL)
- Protein: P19878 (SWISSPROT)
- Other Sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
NCF2, NCF1, and a membrane bound cytochrome B558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Subcellular location:
Cytoplasmic
Structures (PDB)
| 1E96 | Structure Of The Rac/P67Phox Complex |
Domains
SH3 1 domain: 240-299
SH3 2 domain: 457-516
Other features
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| blood, white cells | 22.96 | 1:910 |
| whole blood | 17.09 | 2:2445 |
| mammary gland | 14.50 | 1:1441 |
| lung metatastic chondrosarcoma | 12.96 | 4:6448 |
| lung epithelial cells tissue nos 359-368 | 4.79 | 1:4366 |
| human optic nerve | 4.74 | 1:4406 |
| blood | 3.30 | 2:12646 |
| normal lung epithelial cells tissue nos 369-371 and 380-383 | 3.11 | 1:6713 |
| human fetal eyes | 3.02 | 2:13838 |
| germ cell | 2.08 | 2:20077 |