ImmunoDeficiency Resource (IDR)

Names

HUGO name: ITGB2

Alias(es):

Localization

Reference sequences

Chromosomal location

Maps

Variations / Mutations

• ITGB2base; Mutation registry for leucosyte adhesion deficiency I (LAD-I)

Other gene-based resources

Description

Protein function:

Integrin α-l/β-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins α-m/β-2 and α-x/β-2 are receptors for the IC3B fragment of the third complement component and for fibrinogen. Integrin α-x/β 2 recognizes the sequence g-p-r in fibrinogen α-chain. Integrin α-m/β-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin α-m/β-2 is also a receptor for Factor X. Integrin α-d/β 2 is a receptor for ICAM3 and VCAM1.

Subunit:

Heterodimer of an α and a β subunit. β-2 associates with either α-l, α-m, α-x or α-d.

Subcellular location:

Type I membrane protein

Structures (PDB)

Domains

Extracellular domain: 23-700

Cytoplasmic domain: 724-769

Vwfa-like domain: 124-363

4 cysteine-rich tandem repeats domain: 449-617

Other features

Signal peptide: 1-22

Integrin beta-2: 23-769

Other related resourses:

Expression pattern for human

Animal models

Mouse

Fly

C. elegans