IFNγ1-receptor deficiency

Gene Information

Names

HUGO name: IFNGR1

Alias(es):

  • IFNGR
  • interferon gamma receptor 1
  • Interferon-gamma receptor alpha chain precursor (CDw119)

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Receptor for interferon gamma. Two receptors bind one interferon-gamma dimer.

Subunit:

Monomer.

Subcellular location:

Type I membrane protein.

Post-translational modification:

Phosphorylated at SER/THR residues.

Structures (PDB)

1JRH Complex (Antibody/Antigen)
1FG9 3:1 Complex Of Interferon-γ Receptor With Interferon-γ Dimer

Domains

Extracellular domain: 18-245

    Cytoplasmic domain: 267-489

      Other features

      Signal peptide: 1-17

        Interferon-gamma receptor alpha chain: 18-489

          Disulfide bond: 77-85

            Disulfide bond: 122-167

              Disulfide bond: 195-200

                Disulfide bond: 214-235

                  Other related resourses:

                  Expression

                  Expression pattern for human

                  Tissue Expression (%) Clones
                  gall bladder 12.46 4:2435
                  sciatic nerve 8.65 1:877
                  human skeletal muscle 6.35 9:10746
                  colonic mucosa with ulcerative colitus 6.23 1:1218
                  connective tissue 5.83 1:1301
                  esophagus 5.14 2:2949
                  pheochromocytoma 4.86 1:1560
                  cns, multiple sclerosis lesions 3.88 4:7823
                  T cells from T cell leukemia 3.16 1:2397
                  whole blood 3.10 1:2445

                  Animal models

                  Mouse

                  Fly