IFNγ2-receptor deficiency

Gene Information

Names

HUGO name: IFNGR2

Alias(es):

  • AF-1
  • IFGR2
  • IFNGT1
  • interferon gamma receptor 2
  • interferon-gamma receptor beta chain precursor
  • Interferon-gamma receptor accessory factor-1 Interferon-gamma transducer-1
  • Interferon-gamma transducer-1

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.

Subcellular location:

Type I membrane protein.

Structures (PDB)

Domains

Extracellular domain: 28-247

    Cytoplasmic domain: 269-337

      Other features

      Signal peptide: 1-27

        Interferon-gamma receptor beta chain: 28-337

          Other related resourses:

          Expression

          Expression pattern for human

          Tissue Expression (%) Clones
          normal gingiva (cell line from immortalized keratinocytes) 13.45 1:517
          head and neck 7.29 1:954
          synovial membrane 4.58 1:1518
          leukopheresis 4.58 3:4557
          pheochromocytoma 4.46 1:1560
          lung metatastic chondrosarcoma 4.31 4:6448
          B cells from Burkitt lymphoma 3.24 1:2143
          heart 2.45 13:36928
          pool, placenta 2.36 4:11794
          osteoarthritic cartilage 2.32 1:2999

          Animal models

          Mouse

          Fly