Interleukin-12 (IL-12) p40 deficiency

Gene Information

Names

HUGO name: IL12B

Alias(es):

  • CLMF
  • NKSF2
  • interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)
  • Interleukin-12 beta chain precursor
  • Cytotoxic lymphocyte maturation factor 40 kDa subunit
  • NK cell stimulatory factor chain 2

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting pbmc.

Subunit:

Disulfide-bonded heterodimer of 40 kda and 35 kda subunits. NKsf is essentially a complex of cytokine and soluble receptor.

Subcellular location:

Secreted.

Post-translational modification:

Known to be C-mannosylated in the recombinant protein; it is not yet known for sure if the wild-type protein is also modified.

Structures (PDB)

Domains

Ig-like C2-type domain: 43-97

    Fibronectin type-III domain: 235-320

      Other features

      Signal peptide: 1-22

        Interleukin-12 beta chain: 23-328

          Disulfide bond: 50-90

            Disulfide bond interchain: 199

              Other related resourses:

              Expression

              Expression pattern for human

              Tissue Expression (%) Clones

              Animal models

              Mouse

              Fly