C8 γ-polypeptide deficiency

Gene Information

Names

HUGO name: C8G

Alias(es):

  • complement component 8, gamma polypeptide
  • Complement component C8 gamma chain precursor

Localization

Reference sequences

Chromosomal location

Maps

Protein Information

Description

Protein function:

C8 is a constituent of the membrane attack complex (MAC). C8 binds to the C5b-7 complex, forming the C5b-8 complex. C5-b8 binds C9 and acts as a catalyst in the polymerization of C9. The gamma subunit seems to be able to bind retinol.

Subunit:

C8 is composed of three chains: alpha, beta and gamma. The alpha and gamma chains are disulfide bonded.

Subcellular location:

Secreted.

Other features

Signal peptide: 1-20

    Complement component c8 gamma chain: 21-202

      Disulfide bond interchain (with c8-alpha): 60

        Disulfide bond: 96-188

          Other related resourses:

          Expression

          Expression pattern for human

          Tissue Expression (%) Clones
          gall bladder 45.49 1:2435
          hepatocellular carcinoma 38.93 5:14226
          stomach 7.03 7:110283
          pool, lung+testis+B-cell 5.96 3:55714
          colon 2.58 2:85835

          Animal models

          Mouse

          Fly

          C. elegans