Printable factfile
Gene Information
Names
HUGO name: ZAP70
Alias(es):
- SRK
- STD
- ZAP-70
- syk-related tyrosine kinase
- zeta-chain (TCR) associated protein kinase
- Tyrosine-protein kinase ZAP-70
Localization
Reference sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Associates with the T-cell antigen receptor zeta chain. Plays a role in lymphocyte activation.
Catalytic activity:
ATP + a protein tyrosine = ADP + protein tyrosine phosphate.
Post-translational modification:
Undergoes tyrosine phosphorylation following TCR stimulation.
Structures (PDB)
Domains
SH2 1 domain: 10-102
SH2 2 domain: 163-254
Protein kinase domain: 338-600
Other features
ATP nucleotide phosphate-binding region: 344-352
ATP binding site: 369
Other related resourses:
- InterPro: IPR000719; Euk_pkinase
- InterPro: IPR000980; SH2
- InterPro: IPR001245; Tyr_pkinase
- Pfam: PF00017; SH2
- Pfam: PF00069; pkinase
- SMART: SM00252; SH2
- SMART: SM00219; TyrKc
- PROSITE: PS00107; PROTEIN_KINASE_ATP
- PROSITE: PS00109; PROTEIN_KINASE_TYR
- PROSITE: PS50011; PROTEIN_KINASE_DOM
- PROSITE: PS50001; SH2
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| blood, white cells | 31.34 | 1:910 |
| leukopheresis | 18.78 | 3:4557 |
| blood | 13.53 | 6:12646 |
| leukocyte | 9.53 | 3:8982 |
| thymus, pooled | 9.00 | 1:3169 |
| blood, lymphocyte | 7.55 | 3:11328 |
| germ cell, pooled | 2.39 | 3:35870 |
| uterus, epithelium | 2.16 | 1:13207 |
| germ cell | 1.42 | 1:20077 |
| unclassified | 1.10 | 2:51898 |