Printable factfile
Gene Information
Names
HUGO name: PTPRC
Alias(es):
- CD45
- GP180
- LCA
- T200
- protein tyrosine phosphatase, receptor type, C
- protein tyrosine phosphatase, receptor type, c polypeptide
- Leukocyte common antigen precursor
- CD45 antigen
Localization
Reference sequences
Chromosomal location
Maps
Variations / Mutations
Other gene-based resources
Protein Information
Description
Protein function:
Required for T-cells activation through the antigen receptor. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one.
Catalytic activity:
Protein tyrosine phosphate + H(2)o = protein tyrosine + phosphate
Subcellular location:
Type I membrane protein
Post-translational modification:
Heavily N- and O-glycosylated
Alternative products:
At least 8 isoforms are produced by alternative splicing
Structures (PDB)
Domains
Extracellular domain: 24-575
Cytoplasmic domain: 598-1304
Fibronectin type-III 1 domain: 387-479
Fibronectin type-III 2 domain: 480-571
Protein-tyrosine phosphatase 1 domain: 670-919
Protein-tyrosine phosphatase 2 domain: 961-1235
Other features
Signal peptide: 1-23
Leukocyte common antigen: 24-1304
Other related resourses:
Expression
Expression pattern for human
| Tissue | Expression (%) | Clones |
|---|---|---|
| nasopharynx | 12.00 | 1:646 |
| adipose | 9.13 | 1:849 |
| blood, white cells | 8.52 | 1:910 |
| nose, olfactory epithelium | 6.94 | 1:1116 |
| lymph, T-cell | 6.38 | 7:8503 |
| subchondral bone | 5.82 | 1:1332 |
| lymph | 5.17 | 43:64395 |
| pheochromocytoma | 4.97 | 1:1560 |
| thymus, pooled | 4.89 | 2:3169 |
| chondrosarcoma | 3.81 | 6:12201 |